IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors

Kenya Honda; Tadatsugu Taniguchi

doi:10.1038/nri1900

IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors

Nat Rev Immunol. 2006 Sep;6(9):644-58. doi: 10.1038/nri1900.

Authors

Kenya Honda¹, Tadatsugu Taniguchi

Affiliation

¹ Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.

PMID: 16932750
DOI: 10.1038/nri1900

Abstract

The interferon-regulatory factor (IRF) family of transcription factors was initially found to be involved in the induction of genes that encode type I interferons. IRFs have now been shown to have functionally diverse roles in the regulation of the immune system. Recently, the crucial involvement of IRFs in innate and adaptive immune responses has been gaining much attention, particularly with the discovery of their role in immunoregulation by Toll-like receptors and other pattern-recognition receptors.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cytosol / immunology*
Cytosol / metabolism
Disease
Humans
Interferon Regulatory Factors / immunology*
Interferon Regulatory Factors / metabolism
Receptors, Pattern Recognition / immunology*
Receptors, Pattern Recognition / metabolism
Signal Transduction / immunology*
Toll-Like Receptors / immunology*
Toll-Like Receptors / metabolism

Substances

Interferon Regulatory Factors
Receptors, Pattern Recognition
Toll-Like Receptors