Abstract
Naïve peripheral B cells survive in vivo because of active stimulation by the TNF superfamily ligand B lymphocyte stimulator (BLyS/BAFF). Although the survival promoting properties of BLyS are well known, the signal pathways and molecular effectors that characterize this stimulation are still being elucidated. In this communication, we discuss the signal cascades that effect BLyS dependent survival and the regulation of BLyS induced signaling. We also examine the role of BLyS as a growth factor and propose that BLyS induced metabolic enhancement optimizes the B cell response to BCR and TLR-dependent signaling.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alternative Splicing
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Animals
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Apoptosis
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B-Cell Activating Factor / immunology
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B-Cell Activating Factor / physiology*
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B-Cell Activation Factor Receptor / immunology
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B-Cell Activation Factor Receptor / physiology*
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B-Cell Maturation Antigen / immunology
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B-Cell Maturation Antigen / physiology
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B-Lymphocyte Subsets / cytology*
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B-Lymphocyte Subsets / immunology
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Cell Survival
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Homeostasis
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Humans
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Immunoglobulin Class Switching
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Lymphoma, B-Cell / immunology
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Lymphoma, B-Cell / pathology
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Mice
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Mice, Inbred A
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Models, Immunological
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Neoplasm Proteins / immunology
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Neoplasm Proteins / physiology
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Protein Kinases / physiology
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Recombinant Fusion Proteins / physiology
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Signal Transduction
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Transcription Factors / physiology
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Transfection
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Transmembrane Activator and CAML Interactor Protein / immunology
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Transmembrane Activator and CAML Interactor Protein / physiology
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Tumor Necrosis Factor Ligand Superfamily Member 13 / immunology*
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Tumor Necrosis Factor Ligand Superfamily Member 13 / physiology
Substances
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B-Cell Activating Factor
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B-Cell Activation Factor Receptor
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B-Cell Maturation Antigen
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Neoplasm Proteins
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Recombinant Fusion Proteins
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TNFRSF13B protein, human
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TNFRSF13C protein, human
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TNFRSF17 protein, human
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TNFSF13 protein, human
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TNFSF13B protein, human
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Tnfrsf13b protein, mouse
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Tnfrsf13c protein, mouse
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Tnfrsf17 protein, mouse
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Tnfsf13 protein, mouse
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Tnfsf13b protein, mouse
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Transcription Factors
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Transmembrane Activator and CAML Interactor Protein
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Tumor Necrosis Factor Ligand Superfamily Member 13
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Protein Kinases