Abstract
Pigmented villonodular synovitis is made up of a variety of cells, including round or oval mononuclear cells, fibroblasts, synovial cells and multinucleated giant cells. The mononuclear cells were found to stain positively with anti-lysozyme, anti-alpha-1-antitrypsin, anti-alpha-1-antichymotrypsin and anti-fibronectin. Vimentin was detected in fibroblasts and in lining cells of the synovial membrane as well as in cells of acinus-like structures. The multinuclear giant cells contained lysozyme, alpha-1-antitrypsin and alpha-1-antichymotrypsin but no vimentin.
MeSH terms
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Adult
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Endothelium, Vascular / chemistry
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Endothelium, Vascular / pathology
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Female
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Fibroblasts / chemistry
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Fibroblasts / pathology
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Fibronectins / analysis
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Giant Cells / chemistry
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Giant Cells / pathology
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Humans
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Immunohistochemistry
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Leukocytes, Mononuclear / chemistry
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Leukocytes, Mononuclear / pathology
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Male
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Middle Aged
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Muramidase / analysis
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Retrospective Studies
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Synovial Membrane / chemistry
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Synovial Membrane / pathology*
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Synovitis, Pigmented Villonodular / pathology*
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Vimentin / analysis
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alpha 1-Antichymotrypsin / analysis
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alpha 1-Antitrypsin / analysis
Substances
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Fibronectins
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Vimentin
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alpha 1-Antichymotrypsin
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alpha 1-Antitrypsin
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Muramidase