Abstract
The metastasis associated protein S100A4 is a small calcium binding protein that is associated with metastatic tumors and appears to be a molecular marker for clinical prognosis. Below we discuss its biochemical properties and possible cellular functions in metastasis including cell motility, invasion, apoptosis, angiogenesis and differentiation.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Cell Movement
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Cell Transformation, Neoplastic*
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Disease Progression
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Gene Expression Regulation, Neoplastic*
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Humans
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Neoplasm Invasiveness*
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Neoplasm Metastasis / genetics*
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Neoplasm Metastasis / physiopathology*
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Neoplasms / genetics*
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Neoplasms / pathology*
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Neovascularization, Pathologic
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Phenotype
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Prognosis
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S100 Calcium-Binding Protein A4
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S100 Proteins / genetics*
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S100 Proteins / physiology*
Substances
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S100 Calcium-Binding Protein A4
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S100 Proteins
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S100A4 protein, human