The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome

Arthritis Rheum. 2004 Mar;50(3):999-1001. doi: 10.1002/art.20114.

Authors

Timothy R D J Radstake¹, Barbara Franke, Suzanne Hanssen, Mihai G Netea, Paco Welsing, Pilar Barrera, Leo A B Joosten, Piet L C M van Riel, Wim B van den Berg

Affiliation

¹ University Medical Center Nijmegen, Nijmegen, The Netherlands.

PMID: 15022344
DOI: 10.1002/art.20114

No abstract available

MeSH terms

Adult
Aged
Arthritis, Rheumatoid / diagnostic imaging
Arthritis, Rheumatoid / genetics*
Arthritis, Rheumatoid / physiopathology*
Aspartic Acid / genetics
Case-Control Studies
Female
Gene Frequency
Genetic Predisposition to Disease / genetics*
Genetic Variation*
Genotype
Glycine / genetics
Humans
Male
Membrane Glycoproteins / genetics*
Middle Aged
Phenotype
Polymorphism, Genetic
Radiography
Receptors, Cell Surface / genetics*
Severity of Illness Index
Toll-Like Receptor 4
Toll-Like Receptors

Substances

Membrane Glycoproteins
Receptors, Cell Surface
TLR4 protein, human
Toll-Like Receptor 4
Toll-Like Receptors
Aspartic Acid
Glycine