Association of PADI4 and rheumatoid arthritis: a successful multidisciplinary approach

Jane Worthington; Sally John

doi:10.1016/j.molmed.2003.08.007

Association of PADI4 and rheumatoid arthritis: a successful multidisciplinary approach

Trends Mol Med. 2003 Oct;9(10):405-7. doi: 10.1016/j.molmed.2003.08.007.

Authors

Jane Worthington¹, Sally John

Affiliation

¹ ARC Epidemiology Unit, School of Epidemiology and Health Sciences, Stopford Building, University of Manchester, Oxford Road, M13 9PT, Manchester, UK. jane.worthington@man.ac.uk

PMID: 14557050
DOI: 10.1016/j.molmed.2003.08.007

Abstract

The identification of functionally relevant polymorphisms of peptidylarginine deiminase 4, an enzyme that catalyzes the post-translational citrullination of proteins, as a rheumatoid arthritis gene is one of the most convincing success stories of complex disease gene mapping to date. In addition to an extensive single nucleotide polymorphism-based association study in a Japanese cohort, a range of techniques have been used to validate this finding.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Arthritis, Rheumatoid / genetics*
Arthritis, Rheumatoid / immunology
Arthritis, Rheumatoid / metabolism
Chromosomes, Human, Pair 1 / genetics
Humans
Hydrolases / genetics*
Hydrolases / metabolism
Polymorphism, Single Nucleotide / genetics*
Protein-Arginine Deiminase Type 4
Protein-Arginine Deiminases

Substances

Hydrolases
PADI4 protein, human
Protein-Arginine Deiminase Type 4
Protein-Arginine Deiminases