Viral-associated haemophagocytosis with parvovirus-B19-related pancytopenia

K Muir; W T Todd; W H Watson; E Fitzsimons

doi:10.1016/0140-6736(92)90735-l

Viral-associated haemophagocytosis with parvovirus-B19-related pancytopenia

Lancet. 1992 May 9;339(8802):1139-40. doi: 10.1016/0140-6736(92)90735-l.

Authors

K Muir¹, W T Todd, W H Watson, E Fitzsimons

Affiliation

¹ Department of Haematology, Monklands District General Hospital, Airdrie, UK.

PMID: 1349370
DOI: 10.1016/0140-6736(92)90735-l

Abstract

Viral-associated haemophagocyte syndrome in response to infection with human parvovirus B19 was seen in 2 patients with hereditary spherocytosis. Depressed reticulocyte response during acute parvovirus infection is a known cause of hypoproliferative crises in patients with reduced erythrocyte lifespan; the observation of parvovirus-associated haemophagocytosis could account for the pancytopenia that may accompany human parvovirus B19 infection.

Publication types

Case Reports

MeSH terms

Adult
Blood Transfusion
Bone Marrow Examination
Child
DNA, Viral / blood
Erythema Infectiosum / blood
Erythema Infectiosum / complications*
Erythema Infectiosum / pathology
Histiocytosis, Non-Langerhans-Cell / etiology*
Histiocytosis, Non-Langerhans-Cell / pathology
Humans
Immunoglobulin M / blood
Male
Pancytopenia / blood
Pancytopenia / etiology*
Pancytopenia / therapy
Spherocytosis, Hereditary / complications*

Substances

DNA, Viral
Immunoglobulin M