Abstract
Secondary lymphoid organs provide the necessary microenvironment for the cooperation of antigen-specific T- and B-lymphocytes and antigen-presenting cells in order to initiate an efficient immune response. Remarkable progress in understanding of the mechanisms of lymphoid organogenesis was achieved due to the analysis of various gene-targeted mice. This review primarily focuses on the role of lymphotoxin (LT) in development, maturation and maintenance of secondary lymphoid organs.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Lymphoid Tissue / cytology
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Lymphoid Tissue / growth & development*
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Lymphoid Tissue / immunology
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Lymphotoxin-alpha / deficiency
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Lymphotoxin-alpha / genetics
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Lymphotoxin-alpha / physiology*
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Mice
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Mice, Knockout
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Models, Immunological
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Signal Transduction
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Tumor Necrosis Factor-alpha / deficiency
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Tumor Necrosis Factor-alpha / genetics
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Tumor Necrosis Factor-alpha / physiology
Substances
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Lymphotoxin-alpha
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Tumor Necrosis Factor-alpha