Abstract
BAFF, a member of the TNF family, is a fundamental survival factor for transitional and mature B cells. BAFF overexpression leads to an expanded B cell compartment and autoimmunity in mice, and elevated amounts of BAFF can be found in the serum of autoimmune patients. APRIL is a related factor that shares receptors with BAFF yet appears to play a different biological role. The BAFF system provides not only potential insight into the development of autoreactive B cells but a relatively simple paradigm to begin considering the balancing act between survival, growth, and death that affects all cells.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Autoimmunity
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B-Cell Activating Factor
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B-Cell Activation Factor Receptor
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B-Lymphocytes / cytology*
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B-Lymphocytes / immunology*
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B-Lymphocytes / metabolism
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Cell Survival
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Disease Models, Animal
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Humans
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Immune Tolerance
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Immunoglobulin A / metabolism
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Ligands
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Membrane Proteins / chemistry
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Membrane Proteins / genetics
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Membrane Proteins / metabolism*
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Mice
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Mice, Transgenic
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Receptors, Tumor Necrosis Factor / chemistry
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Receptors, Tumor Necrosis Factor / genetics
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Receptors, Tumor Necrosis Factor / metabolism
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Signal Transduction
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Tumor Necrosis Factor Ligand Superfamily Member 13
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Tumor Necrosis Factor-alpha / chemistry
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Tumor Necrosis Factor-alpha / genetics
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Tumor Necrosis Factor-alpha / metabolism*
Substances
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B-Cell Activating Factor
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B-Cell Activation Factor Receptor
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Immunoglobulin A
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Ligands
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Membrane Proteins
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Receptors, Tumor Necrosis Factor
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TNFRSF13C protein, human
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TNFSF13 protein, human
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TNFSF13B protein, human
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Tnfrsf13c protein, mouse
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Tnfsf13 protein, mouse
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Tnfsf13b protein, mouse
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Tumor Necrosis Factor Ligand Superfamily Member 13
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Tumor Necrosis Factor-alpha