BAFF: a fundamental survival factor for B cells

Fabienne Mackay; Jeffrey L Browning

doi:10.1038/nri844

BAFF: a fundamental survival factor for B cells

Nat Rev Immunol. 2002 Jul;2(7):465-75. doi: 10.1038/nri844.

Authors

Fabienne Mackay¹, Jeffrey L Browning

Affiliation

¹ Garvan Institute of Medical Research, Department of Arthritis and Inflammation, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia. f.mackay@garvan.unsw.edu.au

PMID: 12094221
DOI: 10.1038/nri844

Abstract

B-cell-activating factor of the tumour-necrosis-factor family (BAFF) enhances B-cell survival--a function that is indispensable for B-cell maturation--and has a role in enhancing immune responses. Moreover, the overexpression of BAFF results in severe autoimmune disorders in mice, and elevated serum levels of BAFF occur in some patients who have autoimmune diseases. The elucidation of the role of BAFF has set the stage for a new approach to the treatment of autoimmune disease.

Publication types

Review

MeSH terms

Animals
Autoimmunity / physiology
B-Cell Activating Factor
B-Cell Activation Factor Receptor
B-Lymphocytes / physiology*
Humans
Membrane Proteins / physiology*
Models, Molecular
Receptors, Tumor Necrosis Factor / physiology
Tumor Necrosis Factor-alpha / physiology*

Substances

B-Cell Activating Factor
B-Cell Activation Factor Receptor
Membrane Proteins
Receptors, Tumor Necrosis Factor
TNFRSF13C protein, human
TNFSF13B protein, human
Tumor Necrosis Factor-alpha