A novel superfamily of enzymes that catalyze the modification of guanidino groups

H Shirai; T L Blundell; K Mizuguchi

doi:10.1016/s0968-0004(01)01906-5

A novel superfamily of enzymes that catalyze the modification of guanidino groups

Trends Biochem Sci. 2001 Aug;26(8):465-8. doi: 10.1016/s0968-0004(01)01906-5.

Authors

H Shirai¹, T L Blundell, K Mizuguchi

Affiliation

¹ Dept of Biochemistry, University of Cambridge, Old Addenbrookes Site, 80 Tennis Court Road, CB2 1GA, Cambridge, UK.

PMID: 11504612
DOI: 10.1016/s0968-0004(01)01906-5

Abstract

Three enzymes, peptidyl-arginine deiminase from Porphyromonas gingivalis, arginine deiminase and amidinotransferase are traditionally classified separately. By combining PSI-BLAST and FUGUE, data presented in this article describe how these enzymes belong to a novel superfamily, adopting a common fold and sharing similar catalytic mechanisms.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amidinotransferases / chemistry
Amidinotransferases / metabolism*
Amino Acid Sequence
Catalysis
Guanidines / metabolism*
Hydrolases / chemistry
Hydrolases / metabolism*
Molecular Sequence Data
Porphyromonas gingivalis / enzymology
Protein-Arginine Deiminase Type 4
Protein-Arginine Deiminases
Sequence Homology, Amino Acid

Substances

Guanidines
Amidinotransferases
Hydrolases
Protein-Arginine Deiminase Type 4
Protein-Arginine Deiminases
arginine deiminase