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T-Cell stimulation and regulation: With complements from CD46

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Abstract

Crosslinking of CD46 and CD3 on naïve human CD4+ T-lymphocytes induces interleukin-10 secretion and granzyme B expression. These highly proliferative T-regulatory type 1-like T-regulatory T-cells (Tregs) can suppress an immune response. We propose that this process is important in the prevention of chronic inflammation such as at epithelial borders and in deactivation of a successful immune response. Relative to the latter, once a complement-fixing polyclonal antibody response has been mounted, in most cases, the pathogen will be rapidly destroyed. At this time, the C3b/C4b-bearing immune complexes could initiate the deactivation arm of an immune response by shutting down immunocompetent cells through CD46-generated T-cells. Herein, we review this pathway for the induction of Tregs, focusing on a role for the complement system and especially signaling through CD46 on human T-cells.

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  1. John P. Atkinson

    Present address: Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8045, 63110, St. Louis, MO

Authors and Affiliations

  1. Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8045, 63110, St. Louis, MO

    Claudia Kemper

  2. Department of Pediatrics, Division of Rheumatology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8045, 63110, St. Louis, MO

    James W. Verbsky

  3. Department of Graduate Program in Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8045, 63110, St. Louis, MO

    Jeffrey D. Price

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  4. John P. Atkinson
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Kemper, C., Verbsky, J.W., Price, J.D. et al. T-Cell stimulation and regulation: With complements from CD46. Immunol Res 32, 31–43 (2005). https://doi.org/10.1385/IR:32:1-3:031

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