Regular ArticleInfectious diseases in systemic lupus erythematosus: risk factors, management and prophylaxis
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2021, Translational ResearchCitation Excerpt :Infections in patients with SLE tend to be more frequent during the initial 5 years after diagnosis, which could reflect underlying disease pathogenesis or aggressive immunosuppressive therapy at the outset of disease.18,22 Functional abnormalities in the immune system due to intrinsic factors and the use of immunosuppressive therapies both contribute to infection risk in patients with SLE.20,23,24-27 Immune cells are affected in SLE in both number and function.
Critically ill systemic lupus erythematosus patients referred to the intensive care unit of Fayoum University Hospital: Frequency, complications and outcome
2019, Egyptian RheumatologistCitation Excerpt :The use of large doses of corticosteroids and immunosuppressants increased the risk of infection and cardio- and cerebrovascular diseases accounted for 26% of deaths. It has been reported that the main causes of death for patients with LN were bacterial infection (25%) and ischemic heart disease (20%) or infection (55%), cardiovascular disease (17%), and cerebrovascular disease (14%) [20,27]. SLE patients are a high-risk population for cardiovascular disease with a morbidity rate of 5.8–13% [28].