Abstract
Progress in rheumatology has been remarkable in the past 70 years, favourably affecting quality of life for people with rheumatic and musculoskeletal diseases. Therapeutics have advanced considerably in this period, from early developments such as the introduction of glucocorticoid therapy to the general use of methotrexate and other disease-modifying agents, followed by the advent of biologic DMARDs and, most recently, small-molecule signalling inhibitors. Novel strategies for the use of such agents have also transformed outcomes, as have multidisciplinary nonpharmacological approaches to the management of rheumatic musculoskeletal disease including surgery, physical therapy and occupational therapy. Breakthroughs in our understanding of disease pathogenesis, diagnostics and the use of 'big data' continue to drive the field forward. Critically, the patient is now at the centre of management strategies as well as the future research agenda.
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References
Bijlsma, J. W. et al. Early rheumatoid arthritis treated with tocilizumab, methotrexate, or their combination (U-Act-Early): a multicentre, randomised, double-blind, double-dummy, strategy trial. Lancet 388, 343–355 (2016).
Strehl, C. et al. Defining conditions where long-term glucocorticoid treatment has an acceptably low level of harm to facilitate implementation of existing recommendations: viewpoints from a EULAR task force. Ann. Rheum. Dis. 75, 952–957 (2016).
Svartz, N. Salazopyrin, a new sulphanilamide preparation. Acta Med. Scand. 110, 577–598 (1942).
Weinblatt, M. E. et al. Efficacy of low-dose methotrexate in rheumatoid arthritis. N. Engl. J. Med. 312, 818–822 (1985).
Bakker, M. F. et al. Low-dose prednisone inclusion in a methotrexate-based, tight control strategy for early rheumatoid arthritis: a randomized trial. Ann. Intern. Med. 156, 329–339 (2012).
Smolen, J. et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update. Ann. Rheum. Dis. 76, 960–977 (2017).
Johnsen, A. K. & Weinblatt, M. E. in Rheumatology (eds Hochberg, M. C. et al.) 509–517 (Elsevier, 2011).
Grigor, C. et al. Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial. Lancet 364, 263–269 (2004).
Maini, R. et al. Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. ATTRACT Study Group. Lancet 354, 1932–1939 (1999).
Siebert, S. et al. Cytokines as therapeutic targets in rheumatoid arthritis and other inflammatory diseases. Pharmacol. Rev. 67, 280–309 (2015).
Evaluate Ltd. EvaluatePharma® world preview 2015, outlook to 2020. Evaluate Group http://info.evaluategroup.com/rs/607-YGS-364/images/wp15.pdf (2015).
Yamaoka, K. Janus kinase inhibitors for rheumatoid arthritis. Curr. Opin. Chem. Biol. 32, 29–33 (2016).
European Medicines Agency. EMA/CHMP/32752/2017 Committee for Medicinal Products for Human Use (CHMP). Summary of opinion (initial authorisation) Xeljanz (tofacitinib). EMA http://www.ema.europa.eu/docs/en_GB/document_library/Summary_of_opinion_-_Initial_authorisation/human/004214/WC500220221.pdf (2017).
European Medicines Agency. EMA/CHMP/843822/2016 Committee for Medicinal Products for Human Use (CHMP). Summary of opinion (initial authorisation) Olumiant (baricitinib). EMA http://www.ema.europa.eu/docs/en_GB/document_library/Summary_of_opinion_-_Initial_authorisation/human/004085/WC500218183.pdf (2016).
Daigle, M. E. et al. The cost-effectiveness of total joint arthroplasty: a systematic review of published literature. Best Pract. Res. Clin. Rheumatol. 26, 649–658 (2012).
Leon, L. et al. Orthopedic surgery in rheumatoid arthritis in the era of biologic therapy. J. Rheumatol. 40, 1850–1855 (2013).
Van der Woude, J. A. et al. Knee joint distraction compared to total knee arthroplasty for treatment of end stage osteoarthritis: simulating long-term outcomes and cost-effectiveness. PLoS ONE. 11, e0155524 (2016).
Ruiz, M., Cosenza, S., Maumus, M., Jorgensen, C. & Noël, D. Therapeutic application of mesenchymal stem cells in osteoarthritis. Expert Opin. Biol. Ther. 16, 33–42 (2016).
American College of Rheumatology. ARHP distinguished lecturer hails 50 years of advances. ACR Daily News Live http://www.acrdailynewslive.org/arhp-distinguished-lecturer-hails-50-years-of-advances/ (2015).
Voshaar, M. J., Nota, I., van de Laar, M. A. & van den Bemt, B. J. Patient-centred care in established rheumatoid arthritis. Best Pract. Res. Clin. Rheumatol. 29, 643–663 (2015).
Dörner, T., Egerer, K., Feist, E. & Burmester, G. R. Rheumatoid factor revisited. Curr. Opin. Rheumatol. 16, 246–253 (2004).
Puszczewicz, M. & Iwaszkiewicz, C. Role of anti-citrullinated protein antibodies in diagnosis and prognosis of rheumatoid arthritis. Arch. Med. Sci. 7, 189–194 (2011).
Aletaha, D. et al. Rheumatoid arthritis classification criteria. An American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann. Rheum. Dis. 69, 1580–1588 (2010).
Shi, J. et al. Carbamylation and antibodies against carbamylated proteins in autoimmunity and other pathologies. Autoimmun. Rev. 13, 225–230 (2014).
Ospelt, C. et al. Carbamylation of vimentin is inducible by smoking and represents an independent autoantigen in rheumatoid arthritis. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2016-210059 (2017).
Hargraves, M. M., Richmond, H. & Morton, R. J. Presentation of two bone marrow elements: the 'tart' cell and the 'L.E.' cell. Proc. Staff Meet. Mayo Clin. 23, 25–28 (1948).
Miescher, P. & Fouconnet, M. L'absorption du facteur 'LE' par des noyaux cellulaires isolés [French]. Experimentia 10, 252–254 (1945).
Hiepe, F., Dörner, T. & Burmester, G. R. Editorial overview: antinuclear antibody- and extractable nuclear antigen-related diseases. Int. Arch. Allergy Immunol. 123, 5–9 (2000).
van der Woude, F. J. et al. Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis. Lancet 8426, 425–429 (1985).
Sheehan, N. J. The ramifications of HLA-B27. J. R. Soc. Med. 97, 10–14 (2004).
Haase, A., Landwehr, G. & Umbach, E. (eds) Röntgen Centennial: X-rays in Natural and Life Sciences (World Scientific, 1997).
Larsen, A., Dale, K. & Eek, M. Radiographic evaluation of rheumatoid arthritis. Acta Radiol. Diagn. (Stockh.) 18, 481–491 (1977).
Sharp, J. T. et al. Reproducibility of multiple-observer scoring of radiologic abnormalities in the hands and wrists of patients with rheumatoid arthritis. Arthritis Rheum. 27, 61–64 (1985).
Van der Heijde, D. M., van Riel, P. L., Nuver-Zuwart, H. H., Gribnau, F. W. & van de Putte, L. B. Effects of hydroxochloroquin and sulphasalazine on progression of joint damage in rheumatoid arthritis. Lancet 1846, 1036–1038 (1989).
Greenberg, J. O. Obituary: William H. Oldendorf — a tribute. J. Neuroimaging 3, 148–149 (1993).
Mishra, S. K. & Singh, P. History of neuroimaging: the legacy of William Oldendorf. J. Child Neurol. 25, 508–517 (2010).
Rubin, G. D. Computed tomography: revolutionizing the practice of medicine for 40 years. Radiology 273, S45–S74 (2014).
Two Views. A quick history of the MRI in two views — words and pictures. Two Views http://www.two-views.com/mri-imaging/history.html#sthash.GbJKG4v0.7vGwlRGx.dpbs (2016).
Lassere, M. et al. OMERACT rheumatoid arthritis magnetic resonance imaging studies. Exercise 3: an international multicenter reliability study using the RA-MRI Score. J. Rheumatol. 30, 1366–1375 (2003).
Woo, J. A short history of the development of ultrasound in obstetrics and gynecology. Ob-ultrasound http://www.ob-ultrasound.net/history1.html (2002).
Gompelt, B. M. & Darlington, L. G. Grey scale ultrasonography and evaluation of popliteal cyst. Clin. Radiol. 30, 539–545 (1979).
Graf, R. The diagnosis of congenital hip-joint dislocation by the ultrasonic Combound treatment. Arch. Orthop. Trauma Surg. 97, 117–133 (1980).
Backhaus, M. et al. Guidelines for musculoskeletal ultrasound in rheumatology. Ann. Rheum. Dis. 60, 641–649 (2001).
Maricq, H. R. & LeRoy, E. C. Patterns of finger capillary abnormalities in connective tissue disease by 'widefield' microscopy. Arthritis Rheum. 16, 619–628 (1973).
Cutolo, M., Sulli, A. & Smith, V. Assessing microvascular changes in systemic sclerosis diagnosis and management. Nat. Rev. Rheumatol. 6, 578–587 (2010).
Abdollahi-Roodsaz, S., Abramson, S. B. & Scher, J. U. The metabolic role of the gut microbiota in health and rheumatic disease: mechanisms and interventions. Nat. Rev. Rheumatol. 12, 446–455 (2016).
van der Vlist, M., Kuball, J., Radstake, T. R. & Meyaard, L. Immune checkpoints and rheumatic diseases: what can cancer immunotherapy teach us? Nat. Rev. Rheumatol. 12, 593–604 (2016).
Topol, E. Digital medicine: empowering both patients and clinicians. Lancet 388, 740–741 (2016).
Barnes, C. G. The History of EULAR (EULAR, 2007).
European League Against Rheumatism (EULAR). EULAR mission statement. EULAR https://www.eular.org/eular_mission.cfm (2005).
Acknowledgements
G.R.B.'s research work is supported by the German Science Foundation and the Federal Ministry for Education and Research.
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Burmester, G., Bijlsma, J., Cutolo, M. et al. Managing rheumatic and musculoskeletal diseases — past, present and future. Nat Rev Rheumatol 13, 443–448 (2017). https://doi.org/10.1038/nrrheum.2017.95
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DOI: https://doi.org/10.1038/nrrheum.2017.95
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