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Chemokines as immunotransmitters?

Nature Immunology volume 6, pages 427–428 (2005)Cite this article

Chemokines not only act as chemotactic and chemokinetic molecules but also are inducers of integrin-dependent adhesion. Analysis of an immunological synapse now demonstrates an additional function for chemokines as costimulatory molecules.

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Figure 1: The chemokine receptor CCR5 is recruited at a T cell–B cell synapse (1) and this recruitment probably requires chemokine secretion by the APC1.

Katie Ris

References

  1. Molon, B. et al. Nat. Immunol. 6, 465–471 (2005).

    Article  CAS  Google Scholar 

  2. Kupfer, H., Monks, C.R.F. & Kupfer, A. J. Exp. Med. 179, 1507–1515 (1994).

    Article  CAS  Google Scholar 

  3. Nanki, T. & Lipsky, P.E. J. Immunol. 164, 5010–5014 (2000).

    Article  CAS  Google Scholar 

  4. Taub, D.D., Turcovski-Corrales, S.M., Key, M.L., Longo, D.L. & Murphy, W.J. J. Immunol. 156, 2095–2103 (1996).

    CAS  PubMed  Google Scholar 

  5. Real, E. et al. J. Immunol. 173, 50–60 (2004).

    Article  CAS  Google Scholar 

  6. Dustin, M.L. Immunity 21, 305–314 (2004).

    Article  CAS  Google Scholar 

  7. Donnadieu, E., Bismuth, G. & Trautmann, A. Curr. Biol. 4, 584–595 (1994).

    Article  CAS  Google Scholar 

  8. Shimaoka, M., Takagi, J. & Springer, T.A. Annu. Rev. Biophys. Biomol. Struct. 31, 485–516 (2002).

    Article  CAS  Google Scholar 

  9. Montes, M., McIlroy, D., Hosmalin, A. & Trautmann, A. Int. Immunol. 11, 561–568 (1999).

    Article  CAS  Google Scholar 

  10. Arrieumerlou, C. et al. Eur. J. Immunol. 28, 1877–1885 (1998).

    Article  CAS  Google Scholar 

  11. Thelen, M. Nat. Immunol. 2, 129–134 (2001).

    Article  CAS  Google Scholar 

  12. Stefanova, I. et al. Nat. Immunol. 4, 248–254 (2003).

    Article  CAS  Google Scholar 

Download references

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  1. Institut Cochin, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Paris, 75014, France

    Alain Trautmann

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  1. Alain Trautmann
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Trautmann, A. Chemokines as immunotransmitters?. Nat Immunol 6, 427–428 (2005). https://doi.org/10.1038/ni0505-427

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