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Killing some to make way for others

Limited niche availability restricts the number of long-lived plasma cells that can reside in the bone marrow. New research describes homeostatic regulatory mechanisms that allow newly 'minted' plasma cells to gain entry to such niches.

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Figure 1: Different modes of inhibitory signaling by FcγRIIb on follicular B cells and plasma cells.

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Ravetch, J., Nussenzweig, M. Killing some to make way for others. Nat Immunol 8, 337–339 (2007). https://doi.org/10.1038/ni0407-337

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