Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Gaining insight into PTPN22 and autoimmunity

The protein tyrosine phosphatase PTPN22 (also called LYP) is the leading example of a genetic variant that confers risk of developing diverse human autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, autoimmune thyroid disease and systemic lupus. A new study now shows that the PTPN22 risk-associated variant, Trp620, results in a gain of PTPN22 phosphatase activity in T cells, opening up new avenues for exploring disease mechanisms.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The PTPN22 R620W substitution results in a gain of enzymatic function that is predicted to increase the threshold for TCR signaling.

Katie Ris

References

  1. Bottini, N. et al. Nat. Genet. 36, 337–338 (2004).

    Article  CAS  PubMed  Google Scholar 

  2. Begovich, A.B. et al. Am. J. Hum. Genet. 75, 330–337 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Kyogoku, C. et al. Am. J. Hum. Genet. 75, 504–507 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Velaga, M.R. et al. J. Clin. Endocrinol. Metab. 89, 5862–5865 (2004).

    Article  CAS  PubMed  Google Scholar 

  5. Criswell, L.A. et al. Am. J. Hum. Genet. 76, 561–571 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Begovich, A.B. et al. Am. J. Hum. Genet. 76, 184–187 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. van Oene, M. et al. Arthritis Rheum. 52, 1993–1998 (2005).

    Article  CAS  PubMed  Google Scholar 

  8. Hasegawa, K. et al. Science 303, 685–389 (2004).

    Article  CAS  PubMed  Google Scholar 

  9. Vang, T. et al. Nat. Genet. 37, 1317–1319 (2005).

    Article  CAS  PubMed  Google Scholar 

  10. Carlton, V.E. et al. Am. J. Hum. Genet. 77, 567–581 (2005).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Liston, A., Lesage, S., Gray, D.H., Boyd, R.L. & Goodnow, C.C. Immunol. Rev. 204, 87–101 (2005).

    Article  CAS  PubMed  Google Scholar 

  12. Sakaguchi, N. et al. Nature 426, 454–460 (2003).

    Article  CAS  PubMed  Google Scholar 

  13. Sakaguchi, S. Nat. Immunol. 6, 345–352 (2005).

    Article  CAS  PubMed  Google Scholar 

  14. Atabani, S.F. et al. Eur. J. Immunol. 35, 2157–2162 (2005).

    Article  CAS  PubMed  Google Scholar 

  15. Siminovitch, K.A. Nat. Genet. 36, 1248–1249 (2004).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gregersen, P. Gaining insight into PTPN22 and autoimmunity. Nat Genet 37, 1300–1302 (2005). https://doi.org/10.1038/ng1205-1300

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng1205-1300

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing