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PTPN22 and invasive bacterial disease

Nature Genetics volume 38, pages 499–500 (2006)Cite this article

To the Editor:

Vang et al.1 recently reported that the protein tyrosine phosphatase PTPN22 Trp620 variant is a gain-of-function mutant, resulting in increased PTPN22 phosphatase activity in T cells. This variant is associated with susceptibility to multiple autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus and autoimmune thyroid disease2,3,4,5,6. Based on the observation that Trp620 downregulates T cell responses1, we hypothesized that the PTPN22 R620W polymorphism may be associated with susceptibility to invasive bacterial infection.

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Acknowledgements

S.J.C. is a Wellcome Trust Clinical Research Fellow, and A.V.S.H. is a Wellcome Trust Principal Fellow. C.C.K. is a scholar of the Agency for Science, Technology and Research (A-STAR) of Singapore and a member of the Master of Medicine and Surgery (MBBS) PhD program of the Faculty of Medicine, National University of Singapore.

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Authors and Affiliations

  1. The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK

    Stephen J Chapman, Chiea C Khor, Fredrik O Vannberg & Adrian VS Hill

  2. Oxford Centre for Respiratory Medicine, Churchill Hospital Site, Oxford Radcliffe Hospital, Oxford, OX3 7LJ, UK

    Stephen J Chapman, Nicholas A Maskell, Emma L Hedley & Robert JO Davies

  3. Department of Respiratory Medicine, Royal Berkshire Hospital, Reading, RG1 5AN, UK

    Christopher WH Davies

  4. Department of Paediatrics, John Radcliffe Hospital, Oxford, OX3 9DU, UK

    Shelley Segal & Catrin E Moore

  5. Department of Microbiology, John Radcliffe Hospital, Oxford, OX3 9DU, UK

    Kyle Knox & Derrick W Crook

  6. Centre for Clinical Vaccinology and Tropical Medicine, Oxford, OX3 9DU, UK

    Nicholas P Day

  7. Department of Infection, Centre for Medical Microbiology, University College London, London, NW1 2BU, UK

    Stephen H Gillespie

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  1. Stephen J Chapman
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  2. Chiea C Khor
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Chapman, S., Khor, C., Vannberg, F. et al. PTPN22 and invasive bacterial disease. Nat Genet 38, 499–500 (2006). https://doi.org/10.1038/ng0506-499

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