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VEGF gene therapy: stimulating angiogenesis or angioma-genesis?

The finding that unregulated, continuous delivery of vascular endothelial growth factor to the myocardium causes the formation of hemangiomas and death in mice indicates that more research is required on this potent molecule before clinical trials can proceed.

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Carmeliet, P. VEGF gene therapy: stimulating angiogenesis or angioma-genesis?. Nat Med 6, 1102–1103 (2000). https://doi.org/10.1038/80430

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