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Deregulated c-fos expression interferes with normal bone development in transgenic mice

Abstract

Transgenic mice were generated expressing c-fos genes under the control of the human metallothionein promoter. Although high levels of c-fos messenger RNA were detectable in a variety of tissues, deregulated c-fos expression specifically interferes with normal bone development without inducing malignant tumours.

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Rüther, U., Garber, C., Komitowski, D. et al. Deregulated c-fos expression interferes with normal bone development in transgenic mice. Nature 325, 412–416 (1987). https://doi.org/10.1038/325412a0

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