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Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

Abstract

A major aim in immunology has been to understand how the immune system evokes characteristic responses to infection, foreign tissue grafts and tumours. The current view of immunoregulation is based mainly on studies of lymphocyte subsets, either in vitro1–3 or by adoptive transfer to irradiated recipients4. Many reagents are available for defining T-cell subsets5–8, but only recently have there been helper T-cell-specific antibodies9,10 against the mouse equivalent of the Leu3/T4 (man) and W3/25 (rat) antigens. It is clear that monoclonal antibodies11 will eventually replace antilymphocyte globulin for immunosuppression in organ grafting12,13, but although there has been some clinical success14–16, most monoclonal reagents cause only transient reductions in their target cells in vivo17–20. This uncertainty in the potency of monoclonal antibodies has led some workers to consider them as targeting agents for such highly cytotoxic drugs as ricin A (ref. 21). We show here that unmodified monoclonal antibodies can be extremely effective at depleting cells in vivo and can be used for the selective manipulation of different aspects of the immune response.

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Cobbold, S., Jayasuriya, A., Nash, A. et al. Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature 312, 548–551 (1984). https://doi.org/10.1038/312548a0

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