Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Interferon-neutralizing antibodies in a patient treated with human fibroblast interferon

Nature volume 289, pages 496–497 (1981)Cite this article

Abstract

During recent years clinical trials have shown that human leukocyte Interferon (HuIFN-α) may be useful in the treatment of cancer, but very little has been done concerning the possible use of human fibroblast Interferon (HuIFN-β). Treuner et al.1 recently reported the successful treatment of a nasopharyngeal carcinoma with HuIFN-β: in the course of IFN-therapy a HuIFN-β neutralizing activity appeared in the serum of this patient. We report here that such activity is due to IgG antibodies—this study is the first to present evidence for antigenicity of IFN in a homologous system.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Treuner, J. et al. Lancet i, 817–818 (1980).

    Article  Google Scholar 

  2. Berg, K., Ogburn, C. A., Paucker, K., Mogensen, K. E. & Cantell, K. J. Immun. 114, 640–644 (1975).

    CAS  Google Scholar 

  3. Paucker, K. & Cantell, K. Virology 18, 154–147 (1962).

    Article  Google Scholar 

  4. Levy-Koenig, R. E., Mundy, M. J. & Paucker, K. J. Immun. 104, 785–790 (1970).

    CAS  PubMed  Google Scholar 

  5. Strander, H., Cantell, K., Carlstrom, G. & Jakobson, P. A. J. natn. Cancer. Inst. 51, 733–739 (1973).

    Article  CAS  Google Scholar 

  6. Desmyter, J. et al. Lancet ii, 645–648 (1976).

    Article  Google Scholar 

  7. Treuner, J. et al. J. Interferon Res. (submitted).

Download references

Author information

Authors and Affiliations

  1. Department for Medical Virology and Epidemiology of Virus Diseases, Hygiene Institute, University of Tübingen, D-7400, Tübingen, 1, FRG

    Angelika Vallbracht & B. Flehmig

  2. Division of Hematology, Department of Pediatrics, University of Tübingen, D-7400, Tübingen, 1, FRG

    J. Treuner & D. Niethammer

  3. Dr Rentschler & Co., Laupheim, FRG

    K.-E. Joester

Authors
  1. Angelika Vallbracht
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Treuner
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. B. Flehmig
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K.-E. Joester
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. D. Niethammer
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vallbracht, A., Treuner, J., Flehmig, B. et al. Interferon-neutralizing antibodies in a patient treated with human fibroblast interferon. Nature 289, 496–497 (1981). https://doi.org/10.1038/289496a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/289496a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing