Abstract
The human ATP-binding cassette (ABC) transporters comprise a large family of membrane transport proteins and play a vital role in many cellular processes. The genes provide functions as diverse as peptide transport, cholesterol and sterol transport, bile acid, retinoid, and iron transport. In addition some ABC genes play a role as regulatory elements. Many ABC genes play a role in human genetic diseases, and several are critical drug transport proteins overexpressed in drug resistant cells. Analysis of the gene products allows the genes to be grouped into seven different subfamilies.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
Allikmets, R., and Dean, M. (1998). Methods Enzymol. 292, 116–130.
Allikmets, R., Gerrard, B., Hutchinson, A., and Dean, M.(1996). Hum. Mol. Genet. 5, 1649–1655.
Allikmets, R., Shroyer, N. F., Singh, N., Seddon, J. M., Lewis, R. A., Bernstein, P. S., Peiffer, A., Zabriskie, N. A., Li, Y., Hutchinson, A., Dean, M., Lupski, J. R., and Leppert, M. (1997a). Science 277, 1805–1807.
Allikmets, R., Singh, N., Sun, H., Shroyer, N. F., Hutchinson, A., Chidambaram, A., Gerrard, B., Baird, L., Stauffer, D., Peiffer, A., Rattner, A., Smallwood, P., Li, Y., Anderson, K. L., Lewis, R. A., Nathans, J., Leppert, M., Dean, M., and Lupski, J. R. (1997b). Nat. Genet. 15, 236–246.
Ames, G., and Lecar, H. (1992). FASEB J. 6, 2660–2666.
Bodzioch, M., Orso, E., Klucken, J., Langmann, T., Bottcher, A., Diederich, W., Drobnik, W., Barlage, S., Buchler, C., Porsch-Ozcurumez, M., Kaminski, W. E., Hahmann, H. W., Oette, K., Rothe, G., Aslanidis, C., Lackner, K. J., and Schmitz, G. (1999). Nat. Genet. 22, 347–351.
Brooks-Wilson, A., Marcil, M., Clee, S. M., Zhang, L. H., Roomp, K., van Dam, M., Yu, L., Brewer, C., Collins, J. A., Molhuizen, H. O., Loubser, O., Ouelette, B. F., Fichter, K., Ashbourne-Excoffon, K.J., Sensen, C. W., Scherer, S., Mott, S., Denis, M., Martindale, D., Frohlich, J., Morgan, K., Koop, B., Pimstone, S., Kastelein, J. J., and Hayden, M. R. (1999). Nat. Genet. 22, 336–345.
Chen, H., Rossier, C., Lalioti, M. D., Lynn, A., Chakravarti, A., Perrin, G., and Antonarakis, S. E. (1996). Am. J. Hum. Genet. 59, 66–75.
Cohn, J. A., Friedman, K. J., Noone, P. G., Knowles, M. R., Silverman, L. M., and Jowell, P. S. (1998). N. Engl. J. Med. 339, 653–658.
Cremers, F. P., van de Pol, D. J., van Driel, M., den Hollander, A. I., van Haren, F. J., Knoers, N. V., Tijmes, N., Bergen, A. A., Rohrschneider, K., Blankenagel, A., Pinckers, A. J., Deutman, A.F., and Hoyng, C. B. (1998). Hum. Mol. Genet. 7, 355–362.
Decottignies, A., and Goffeau, A. (1997). Nat. Genet. 15, 137–145.
Higgins, C. F. (1992). Annu. Rev. Cell. Biol. 8, 67–113.
Higgins, C. F., Hiles, I. D., Slamond, G. P. C., Gill, D. R., Downie, J. A., Evans, I. J., Holland, B., Gray, L., Buckel, S. D., Bell, A. W., and Hermodson, M. A. (1990). Nature 323, 448–450.
Klucken, J., Buchler, C., Orso, E., Kaminski, W. E., Porsch-Ozcurumez, M., Liebisch, G., Kapinsky, M., Diederich, W., Drobnik, W., Dean, M., Allikmets, R., and Schmitz, G. (2000). Proc. Natl. Acad. Sci. U.S.A. 97, 817–822.
Langmann, T., Klucken, J., Reil, M., Liebisch, G., Luciani, M. F., Chimini, G., Kaminski, W. E., and Schmitz, G. (1999). Biochem. Biophys. Res. Commun. 257, 29–33.
Lewis, R. A., and Lupski, J. R. (2000). Hosp. Pract. (Off. Ed.) 35, 41–50, 56–58.
Luciani, M. F., Denizot, F., Savary, S., Mattei, M. G., and Chimini, G. (1994). Genomics 21, 150–159.
Marcil, M., Brooks-Wilson, A., Clee, S. M., Roomp, K., Zhang, L. H., Yu, L., Collins, J. A., van Dam, M., Molhuizen, H. O., Loubster, O., Ouellette, B. F., Sensen, C. W., Fichter, K., Mott, S., Denis, M., Boucher, B., Pimstone, S., Genest, J. Jr., Kastelein, J. J., and Hayden, M. R. (1999). Lancet 354, 1341–1346.
Martinez-Mir, A., Bayes, M., Vilageliu, L., Grinberg, D., Ayuso, C., del Rio, T., Garcia-Sandoval, B., Bussaglia, E., Baiget, M., Gonzalez-Duarte, B., and Balcells, S. (1997). Genomics 40, 142–146.
Michaelis, S., and Berkower, C. (1995). Sequence comparison of yeast ATP binding cassette (ABC) proteins. In Cold Spring Harbor Symposium, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
Mickley, L., Jain, P., Miyake, K., Schriml, L. M., Rao, K., Fojo, T., Bates, S., and Dean, M. (2001). Mamm. Genome. 12, 86–88.
Mosser, J., Douar, A. M., Sarde, C. O., Kioschis, P., Feil, R., Moser, H., Poustka, A. M., Mandel, J. L., and Aubourg, P. (1993). Nature 361, 726–730.
Moynault, A., Luciani, M. F., and Chimini, G. (1998). Biochem. Soc. Trans. 26, 629–635.
Pepling, M., and Mount, S. M. (1990). Nucl. Acids Res. 18, 1633.
Riordan, J. R., Rommens, J. M., Kerem, B., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J. L., et al. (1989). Science 245, 1066–1073.
Rust, S., Rosier, M., Funke, H., Real, J., Amoura, Z., Piette, J. C., Deleuze, J. F., Brewer, H. B., Duverger, N., Denefle, P., and Assmann, G. (1999). Nat. Genet. 22, 352–355.
Schriml, L. M., and Dean, M. (2000). Genomics 64, 24–31.
Sharer, N., Schwarz, M., Malone, G., Howarth, A., Painter, J., Super, M., and Braganza, J. (1998). N. Engl. J. Med. 339, 645–652.
Shulenin, S., Schriml, L. M., Remaley, A. T., Fojo, S., Brewer, B., Allikmets, R., and Dean, M. (2001). Cytogenet. Cell Genet. 92, 204–208.
Sun, H., Molday, R. S., and Nathans, J. (1999). J. Biol. Chem. 274, 8269–8281.
Tsui, L. C. (1995). Am. J. Respir. Crit. Care. Med. 151, S47–S53.
Rights and permissions
About this article
Cite this article
Dean, M., Allikmets, R. Complete Characterization of the Human ABC Gene Family. J Bioenerg Biomembr 33, 475–479 (2001). https://doi.org/10.1023/A:1012823120935
Issue Date:
DOI: https://doi.org/10.1023/A:1012823120935