13th Congress of the Middle East Society for Organ Transplantation (MESOT)Renal transplantationLong-Term Outcome of Renal Transplantation in Patients With Familial Mediterranean Fever Amyloidosis: A Single-Center Experience
Section snippets
Patients And Method
We compared the results of RTX in 18 patients with FMF amyloidosis among 60 1(2.9%) transplants with 200 age- and gender-matched, non-FMF RTX patients as controls. In 2 groups, immunosuppression and duration of transplantation were similar. All patients has MEFV mutation analysis and renal biopsy before RTX. Blood urea, creatinine, urinalysis, and cyclosporine levels were measured monthly and 24-hour proteinuria every 3 months. Demographic data, transplantation duration, blood pressure,
Results
We included 18 patients (12 men and 6 women) with FMF amyloidosis with a mean age of 40.52 ± 7.1 years among 601 (2.9%) transplants with 200 controls (120 men and 80 women) with a mean age of 41.93 ± 10.93 years (P < .2). Mean transplantation duration was 76.42 ± 11.66 in FMF and 72 ± 12.14 in controls. Mean blood urea and creatinine in FMF group was 44.05 ± 9.34 and 1.43 ± 0.54 mg/dL 1 year after RTX without being different from controls (44.26 ± 10.4). Blood urea and 1.39 ± 0.30 creatinine (P
Discussion
FMF as an autosomal-recessive disease characterized with recurrent episodes of fever and serositis affects kidneys, by development of type AA amyloidosis causes proteinuria and nephropathy and leads to ESRD after 2 to 13 years.8
RTX remains treatment of choice for ESRD owing to FMF amyloidosis compared with hemodialysis or peritoneal dialysis, because of the higher morbidity and mortality rates of these patients on dialysis.2, 9 FMF accounted for 2% to 4% of all RTX in a study by Sherif et al2
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