Rheumatoid ArthritisFactors associated with adherence to pharmaceutical treatment for rheumatoid arthritis patients: A systematic review
Section snippets
Literature search
EMbase, PubMed, CINAHL and PsycINFO databases were searched from inception to February 2011 to identify studies on factors affecting medication adherence in patients with RA (see search strategy in Appendix 1. Studies were eligible if they (i) addressed medication adherence in adult RA or undifferentiated inflammatory arthritis patients, (ii) evaluated factors related to adherence, (iii) used a reproducible definition or validated instrument to measure adherence, and (iv) provided a statistical
Results
Out of the 1479 identified studies, 135 articles were potentially relevant regarding the content of title and abstract and retrieved as full-text articles. After applying the inclusion criteria 17 articles remained eligible for the review. One relevant additional study was identified from the reference lists, resulting in 18 included studies (see flowchart Fig. 1). Data were extracted from each study and summarized in Table 3, Table 4, Table 5, Table 6 and presented in full detail in the
Discussion
Our study used a systematic literature search to identify and summarize data on adherence rates in RA and undifferentiated inflammatory arthritis, to identify factors influencing adherence to pharmaceutical treatment and to identify the strength of the association between these factors and adherence. Overall 18 studies that fulfilled the inclusion criteria examined the relationship between adherence and factors thought to influence adherence, of which none studied undifferentiated inflammatory
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