BCP crystals increase prostacyclin production and upregulate the prostacyclin receptor in OA synovial fibroblasts: potential effects on mPGES1 and MMP-131
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Key words
Prostacyclin
Basic calcium phosphate crystals
Osteoarthritis
Synovial fibroblasts
Prostacyclin receptor
Microsomal prostaglandin E2 synthase 1
Matrix metalloproteinases
Abbreviations
BCP
basic calcium phosphate
COX
cyclooxygenase
DMEM
Dulbecco's modified Eagles medium
FBS
fetal bovine serum
HFF
human foreskin fibroblasts
IL-1β
interleukin-1β
IP
prostacyclin receptor
MMP
matrix metalloproteinase
mPGES1
microsomal prostaglandin E2 synthase 1
NSAIDs
non-steroidal anti-inflammatory drugs
OA
osteoarthritis
OASF
osteoarthritic synovial fibroblasts
PGE2
prostaglandin E2
PGI2
prostaglandin I2 (prostacyclin)
PGIS
prostacyclin synthase
s.e.m.
standard error of the mean
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Funded by the Health Research Board, Wellcome Trust and the PRTLI Cycle III.
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The authors have no conflict of interest to declare.
Copyright © 2006 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.