ReportPrevalence of cardiovascular risk factors in patients with psoriasis
Section snippets
Study design
This was a cross-sectional (prevalence) study with data collected by general practitioners (GPs) in the United Kingdom (UK), who were participating in the General Practice Research Database (GPRD) between 1987 and 2002. GPs were unaware of the hypothesis to be tested. The data were collected as part of the patient's electronic medical record and are maintained in the GPRD. GPRD contains data on more than 9 million persons with more than 35 million person-years of follow-up time and is broadly
Results
We identified 127,706 patients with mild psoriasis who were matched with 465,252 subjects without psoriasis and 3854 patients with severe psoriasis matched to 14,065 corresponding subjects without psoriasis (Table I). Psoriasis patients were slightly older than matched control patients and were more likely to be male than the controls. In addition, person-years of observation were slightly greater in both psoriasis groups compared with their respective control groups (Table I). Information on
Discussion
The results of this study suggest that diabetes, hypertension, hyperlipidemia, smoking, and increased BMI are associated with both mild and severe psoriasis. Additionally, these diseases are all independently associated with mild psoriasis; however, except for obesity and smoking, the association was negligible to modest for most of the cardiovascular risk factors and therefore unlikely to be of clinical significance. The association with severe psoriasis when controlling for traditional
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Supported by grant K23 AR051125-01 from the National Institutes of Health and the National Institute for Arthritis, Musculoskeletal, and Skin Diseases (to J. M. G.).
Conflicts of interest: None identified.