ReviewTowards a better understanding of the clinical association of anti-DFS70 autoantibodies
Section snippets
Take-home messages
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potential clinical associations of anti-DFS70 antibodies remains speculative and future, well defined, studies are required to provide more insights.
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HEp-2 cells can be used to screen for anti-DFS70 antibodies, but their presence should be confirmed using a specific test for anti-DFS70 antibodies (i.e. ELISA, CIA or by immunoadsorption).
Competing interests
M. Mahler is employed at Inova Diagnostics selling autoantibody assays. The other authors received consultant fees from Inova Diagnostics in the past.
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2021, Journal of Immunological MethodsCitation Excerpt :There is significant clinical utility in the use of anti-DFS70/LEDGF as a marker of exclusion, but limited information remains regarding the role the autoantibodies play in the pathogenesis of patients' symptoms and whether the autoantibodies are indeed associated with a particular disease or diseases. No specific clinical associations have been confirmed (Mahler et al., 2016), which has translated to confusion, misunderstanding, and diagnostic dilemmas. The purpose of this study was to determine the prevalence of SARD among a group of ANA-DFS positive individuals and to identify the final diagnoses among the non-SARD individuals in order to determine possible clinical associations.
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