Original articlePhysical Function and Properties of Quadriceps Femoris Muscle in Men With Knee Osteoarthritis
Section snippets
Participants and Selection
We recruited study subjects by a local newspaper advertisement from the city of Kuopio, Finland and its neighboring area between December 2004 and April 2005. Subjects (n=54) were selected by clinical criteria for uni- or bilateral knee OA. Subjects had experienced pain or functional impairment (eg, limitation of knee motion or stiffness of the joint) in the knee region within the prior month as indicated in the clinical criteria of the American College of Rheumatology.36 The exclusion criteria
Characteristics of the Study Participants
The clinical features of the groups are shown in table 1. The patients with knee OA had 9.6% (P=.001) higher BMI than the control subjects. OA subjects showed significantly poorer HRQOL in 7 of the 8 separate scales as measured by the RAND-36, version 1.0. The HRQOL did not differ between the knee OA subgroups. There were no significant differences between the groups in terms of leisure-time physical activity (OA subjects, 429±319 sessions/y vs control subjects, 350±208 sessions/y). The work
Discussion
The patients with knee OA exhibited significantly poorer physical function and lower knee extension and flexion muscle strength compared with age- and sex-matched control subjects. The mean decline of performance ranged from about 13% to 26% in the patient group. Furthermore, the RAND-36 survey revealed that patients with knee OA showed significantly impaired HRQOL in almost all of the measured separate scales compared with the control subjects. There were also significant differences in QFM
Conclusions
The patients with knee OA exhibited impaired physical function and muscle strength, as well as deteriorated QFM composition compared to healthy controls. The severity of radiographic knee OA was clearly reflected in objectively and subjectively assessed disability, but only in the later stage of the disease. The results highlight the effect of QFM strength on physical function as well as the importance of subjective and objective physical functioning abilities of the patient when considering
Acknowledgment
We thank Vesa Kiviniemi, PhL, from the University of Kuopio, for his significant help in the statistical analyses.
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Supported by EVO from Kuopio University Hospital (grant no. 5960416) and by the Prosthesis Foundation.
No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit on the authors or on any organization with which the authors are associated.