Trends in Immunology
Volume 22, Issue 12, 1 December 2001, Pages 662-663
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Defective clearance of nucleosomes and systemic lupus erythematosus

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  • Cited by (10)

    • Endothelial cell apoptosis in systemic lupus erythematosus: A common pathway for abnormal vascular function and thrombosis propensity

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      Thus, on the basis of our observations at least in stable CAD, release of apoptotic cells into the circulation does not seem to occur to the degree observed in SLE. The presence of circulating apoptotic ECs in SLE, but not in stable CAD, argues for additional defects in clearance of these cells in SLE and/or inappropriately high rates of apoptosis in combination with additional defects in marrow reserve, as potential mechanisms.48,49 Statins have been reported to improve arterial function in patients with CAD in the presence of risk factors such as hyperlipidemia, diabetes, and smoking.50

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