Human COL9A1 and COL9A2 genes. Two genes of 90 and 15 kb code for similar polypeptides of the same collagen molecule

doi:10.1016/S0945-053X(98)90063-4

Matrix Biology

Volume 17, Issue 3, July 1998, Pages 237-241

https://doi.org/10.1016/S0945-053X(98)90063-4 Get rights and content

Abstract

Here we report the complete structure for the human COL9A1 and the complete sequence for the human COL9A2 genes. The COL9A1 gene is about 90 kb and consists of 38 exons. The COL9A2 gene is only about 15 kb, and it contains 32 exons. Sequence analysis of the promoter regions for the human COL9A2, the mouse Col9a2 and the human COL2A1 genes identified a conserved 14 bp sequence. The data also indicated that the alternative exon 1^∗ found in intron 6 of the COL9A1 gene is separated from exon 7 only by a short intron in the chick, human, mouse and rat genes probably explaining why transcripts from exon 1^∗ are spliced directly to exon 8.

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Human COL9A1 and COL9A2 genes. Two genes of 90 and 15 kb code for similar polypeptides of the same collagen molecule

Abstract

J. Biol. Chem.

J. Biol. Chem.

FEBS Lett.

Meth. Enzymol.

J. Biol. Chem.