Effect of Interleukin-1 and Insulin Like Growth Factor-1 on the Release of Proteoglycan Components and Hyaluronan from Pig Articular Cartilage in Explant Culture
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2023, European Journal of Pharmaceutics and BiopharmaceuticsBiology of Proteoglycans and Associated Glycosaminoglycans
2021, Comprehensive Glycoscience: Second EditionThe pericellular hyaluronan of articular chondrocytes
2019, Matrix BiologyCitation Excerpt :In some studies, HA turnover occurs in close proportion to the turnover of aggrecan [6,38–43] whereas in others, HA turnover is greater than [43,44] or less than [36] the turnover of aggrecan. In some cases, large amounts of partially-degraded HA are released from cartilage [39–41] and others, as noted above, only a small fraction is released [35,37]. How can we make sense of these patterns?
Cellular and molecular mechanisms of cartilage damage and repair
2014, Drug Discovery TodayCitation Excerpt :Some of these discrepancies can be explained by focal production of inflammatory cytokines but also by temporal dynamics: episodes of inflammation that can be short-lived but can lead to accruing damage. Functionally, IL-1 treatment induces intense aggrecanolysis [30] and upregulates cartilage-degrading enzymes such as MMPs [31] and ADAMTS-4 and/or -5 expression [32]. IL-1β can also suppress the synthesis of the cartilage ECM components [33].
- a
Present address: Dept. of Medicine, University of Melbourne Royal Melbourne Hospital, Parkville, Victoria, Australia
- b
Dr. T. E. Hardingham, Head, Biochemistry Division, Kennedy Institute of Rheumatology, 6 Bute Gardens, Hammersmith, London W6 7DW, UK.