A cohort study (with re-sampled comparator groups) to measure the association between new NSAID prescribing and upper gastrointestinal hemorrhage and perforation☆
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Cited by (41)
Gastrointestinal Safety of Cyclooxygenase-2 Inhibitors: A Cochrane Collaboration Systematic Review
2007, Clinical Gastroenterology and HepatologyIncidence of serious upper gastrointestinal bleeding/perforation in the general population: Review of epidemiologic studies
2002, Journal of Clinical EpidemiologyEpidemiologic assessment of the safety of conventional nonsteroidal anti-inflammatory drugs
2001, American Journal of MedicineCitation Excerpt :The associations presented below were adjusted for antecedents of upper gastrointestinal disorders and aspirin use. Current intake of NSAIDs, studied as a therapeutic class, has been associated with a fourfold to fivefold increase in UGIB.2–19 We found an RR of 4.1 (95% CI: 3.5 to 4.7; Table 1).
Gastrointestinal toxicity associated with nonsteroidal anti-inflammatory drugs: Epidemiologic and economic issues
2001, Gastroenterology Clinics of North AmericaCitation Excerpt :The study was unable to provide information on the newer NSAIDs (e.g., nabumetone, etodolac) and those that had not yet been introduced (celecoxib, meloxicam, rofecoxib). Generally, similar findings were produced in a subsequent analysis of the Tayside, Scotland, data for persons without prior gastrointestinal events, history of endoscopy, or use of antisecretory agents and adjusted for age and gender.69 Using data from the Saskatchewan database, Gutthann et al42 estimated the risk of complicated peptic ulcer for persons without a prior history of complicated peptic ulcer and adjusted their data for age, gender, corticosteroid use, prescription aspirin, and calendar year.
The use of anti-inflammatory drugs in cancer pain
2001, Cancer Treatment ReviewsNonsteroidal anti-inflammatory drug-gastropathy and enteropathy
2019, Evidence-based Gastroenterology and Hepatology
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The Medicines Monitoring Unit is supported by the Medicines Control Agency. The present study was funded in part by a grant from Glaxo-Wellcome PLC. There were no conflicts of interest.