BOWEL INFLAMMATION AND THE SPONDYLOARTHROPATHIES
Section snippets
Prevalence of Gut Abnormalities in Spondyloarthropathies
Since the first report on subclinical gut inflammation in SpA patients, 88 revealed by ileocolonoscopy, exploring the whole colon, cecum, and terminal ileum, several authors have confirmed these findings in different forms of spondyloarthropathy (SpA). 3, 29, 32, 49, 66, 67, 95, 137 The prevalence of macroscopic and microscopic signs of gut inflammation reported by the respective authors is listed in Table 1. In enterogenic ReA, macroscopic lesions were found in approximately 50% of patients,
RHEUMATIC MANIFESTATIONS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE
Rheumatic symptoms are the most common extraintestinal manifestations in patients with IBD. In some cases, the occurrence of arthritis is related to the presence of other extraintestinal manifestations, such as uveitis and erythema nodosum. The peripheral arthritis and the spondylitis occurring in patients with IBD are considered as enteropathic arthritides. Other locomotor extraintestinal manifestations include granulomatous joint and bone involvement, periostitis, clubbing, and osteoporosis.
The Gut in Animal Models of Spondyloarthropathy
The challenging link between gut inflammation and arthropathies in humans has also been documented in some animal models of SpA. HLA-B27 transgenic rats provide the first and most convincing model in which a relationship between gut and synovial inflammation was observed. Several lines of rats transgenic for various class 1 HLA heavy chains and human β2m-microglobulin (hβ2m) genes have been established. 51 Half of the lines expressing HLA-B27 and hβ2m develop a spontaneous, multisystem,
References (146)
- et al.
Leucocyte-endothelial interactions and regulation of leucocyte migration
Lancet
(1994) - et al.
Side effects of nonsteroidal antiinflammatory drugs on the small and large intestine in humans
Gastroenterology
(1993) - et al.
Intestinal permeability and inflammation in rheumatoid arthritis: Effects of non-steroidal anti-inflammatory drugs
Lancet
(1984) - et al.
Second-line treatment in seronegative spondylarthropathies
Semin Arthritis Rheum
(1994) - et al.
Ileocolonoscopy in seronegative spondylarthropathy
Gastroenterology
(1989) Do bacterial antigens cause reactive arthritis?
Rheum Dis Clin North Am
(1992)- et al.
Salmonella lipopolysaccharide in synovial cells from patients with reactive arthritis
Lancet
(1990) - et al.
Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: An animal model of HLA-B27 associated human disorders
Cell
(1990) - et al.
HLA-B27-restricted CD8 T cells derived from synovial fluid of patients with reactive arthritis and ankylosing spondylitis
Lancet
(1993) - et al.
Salmonella-triggered reactive arthritis
Lancet
(1992)
European Cooperative Disease Study (ECDS): Results of drug treatment
Gastroenterology
Arthritis accompanying ulcerative colitis
Am J Med
Inflammation of the ileum in patients with B27-positive reactive arthritis
Lancet
Course of gut inflammation in spondylarthropathies and therapeutic consequences
Baillieres Clin Rheumatol
Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs
N Engl J Med
Clinical silent inflammatory gut lesions in undifferentiated spondyloarthropathies
Clin Rheumatol
An experiment to determine the active therapeutic moiety of sulfasalazine
Lancet
Bowel inflammation in anterior uveitis and spondylarthropathy
J Rheumatol
Coxites destructives de la maladie de Crohn
Presse Médical
Arthritis and celiac disease
Ann Rheum Dis
Use of immunohistologic and in situ hybridization techniques in the examination of sacroiliac joint biopsy specimens from patients with ankylosing spondylitis
Arthritis Rheum
Three colour flow cytometric examination of CD4/CD45 subsets reveals no difference in peripheral blood and synovial fluid between patients with reactive arthritis and rheumatoid arthritis
Clin Exp Rheumatol
Immunology of reactive arthritides
Ann Rev Immunol
Lymphocyte adherence to high endothelial venules: Characterization of a modified in vitro assay, and examination of the binding of syngeneic and allogeneic lymphocyte populations
J Immunol
Organ specificity of lymphocyte migration: Mediation by highly selective lymphocte interaction with organ-specific determinants on high endothelial venules
Eur J Immunol
A proteoglycan (aggrecan)-specific T cell hybridoma induces arthritis in BALB/c mice
J Immunol
Nonsteroidal antiinflammatory drugs and complicated diverticular disease: A case control study
Br J Surg
Comparison of sulfasalazine and placebo in the treatment of ankylosing spondylitis
Arthritis Rheum
Comparison of sulfasalazine and placebo in the treatment of psoriatic arthritis
Arthritis Rheum
Comparison of sulfasalazine and placebo in the treatment of reactive arthritis (Reiter's syndrome)
Arthritis Rheum
Circulating immune complexes containing secretory IgA in jejunoileal bypass disease
Ann Rheum Dis
The adhesion molecules of inflammation
Arthritis Rheum
Histopathology of intestinal inflammation related to reactive arthritis
Gut
Immunoglobulin containing cells in terminal ileum and colorectum of patients with arthritis related gut inflammation
Gut
M-cells are damaged and increased in number in inflamed human ileal mucosa
Histopathology
Extraintestinal manifestations of idiopathic inflammatory bowel disease
Arch Intern Med
Toxicity of nonsteroidal anti-inflammatory drugs in the large intestine
Dis Colon Rectum
Yersinia in intestinal biopsy specimens from patients with seronegative spondylarthropathy: Correlation with specific serum IgA antibodies
J Infect Dis
Controlled trial of sulfasalazine in the treatment of ulcerative colitis
Gut
A controlled trial of long-term maintenance treatment of ulcerative colitis with sulfasalazine
Gut
Ilécolonoscopie systhématique au cours de spondylarthropathies séronégatives
Rev Rhum
Sulfasalazine in ankylosing spondylitis
Br Med J
Use of sulfasalazine for the prevention of attacks of acute anterior uveitis associated with spondylarthropathy
Arthritis Rheum
The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy
Arthritis Rheum
Sulfasalazine in the treatment of spondylarthropathy: A randomized, multicenter, double-blind, placebo-controlled study
Arthritis Rheum
Non-steroidal anti-inflammatory drugs are associated with emergency admission to hospital for colitis due to inflammatory bowel disease
Gut
Sulfasalazine in ankylosing spondylitis
Ann Rheum Dis
Sulfasalazine in the management of psoriatic arthritis
Br J Rheumatol
Synovial T lymphocyte recognition of organisms that trigger reactive arthritis
Clin Exp Immunol
Sulfasalazine in the treatment of pauciarticular onset juvenile chronic arthritis
Clin Rheumatol
Cited by (0)
Address reprint requests to Dr. Eric Veys University Hospital Ghent Department of Rheumatology De Pintelaan 185 B-9000 Gent Belgium
Supported by NFWO grant 3.0028.95 and 3.0022.96 and by a concerted action grant GOA96001 of the University of Belgium. Dr. Elewaut is a NFWO Research Assistant.