Apoptosis: Pathophysiology of Programmed Cell Death
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Cited by (72)
Preauricular solitary fibrous tumor: A case report of uncommon neoplasm arising from the facial region
2020, Journal of Oral and Maxillofacial Surgery, Medicine, and PathologyCitation Excerpt :However, cellular forms of SFT tend to be less frequently positive for CD34; when positive, the staining is usually less strong than in fibrous SFT and often focal [5]. The function of bcl-2 oncoprotein is associated with the inhibition of apoptosis [30,31]. Some studies have reported that the expression of bcl-2 in SFT has no relation to whether the SFT is malignant or not [18,32,33].
Cigarette smoke condensate may disturb immune function with apoptotic cell death by impairing function of organelles in alveolar macrophages
2018, Toxicology in VitroCitation Excerpt :Furthermore, cell debris can stimulate infiltration of surrounding immune cells as foreign materials (Bosman et al., 1996). Apoptotic cell death can be initiated by both intrinsic and extrinsic pathways, and the intrinsic pathway can be triggered by structural or functional damage of organelles (Elmore, 2007; Bosman et al., 1996). For instance, the endoplasmic reticulum (ER) houses intracellular stores of Ca2+, which acts as a second messenger in numerous physiological processes including protein synthesis, cell signaling, cell cycle regulation, metabolism, gene transcription, muscle contraction, and nerve conduction.
The tumor antagonistic steroidal alkaloid Solanidine prompts the intrinsic suicidal signal mediated DFF-40 nuclear import and nucleosomal disruption
2018, Life SciencesCitation Excerpt :Deregulation of this balance can add to either formation of the tumor or improper tissue loss through apoptosis. Being important regulatory mechanism in physiological and pathological conditions, better understanding of the regulatory mechanisms and targeting them for therapeutic approach through effective pharmacophore is upcoming strategy [38]. The strategy will effectively translate and selectively target deregulated signaling pathways in cancer cells which will pave the new path to bypass cancer cells treatment resistance [39].
Morphologic Manifestations of Toxic Cell Injury
2013, Haschek and Rousseaux's Handbook of Toxicologic PathologyMorphologic Manifestations of Toxic Cell Injury
2013, Haschek and Rousseaux's Handbook of Toxicologic Pathology, Third Edition: Volume 1-3
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F. T. Bosman (Present Address), Department of Pathology, University of Lausanne, Rue du Bugnon 25, CH-1011 Lausanne, Switzerland