Research LettersPlasma adrenomedullin in diabetes
References (5)
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Production and secretion of adrenomedullin from vascular smooth muscle cells: augmented production by tumor necrosis factor-alpha
Biochem Biophys Res Commun
(1994) - et al.
Endothelial cells actively synthesize and secrete adrenomedullin [published erratum appears in Biochem Biophys Res Commun 1994; 203: 1363]
Biochem Biophys Res Commun
(1994)
Cited by (86)
Higher serum adrenomedullin concentration is associated with an increased risk of gestational diabetes mellitus: A nested case-control study in Wuhan, China
2022, Nutrition ResearchCitation Excerpt :In addition, several studies proved that MR-proADM was a reliable substitute for the determination of ADM concentration [20–22]; therefore, circulating MR-proADM was measured in the present study, which reflected the amount of ADM released. Our findings of a positive association between serum ADM concentration and subsequent odds of GDM were in accordance with studies on type 2 diabetes among nonpregnant individuals [44,45]. Similar to our findings, Dong et al. demonstrated that the plasma ADM concentration of pregnant women in the GDM group (n = 11) was much higher than that in the normal glucose tolerance control group (n = 10) [33].
Plasma adrenomedullin level and year-by-year variability of body mass index in the general population
2021, PeptidesCitation Excerpt :eGFR was calculated with the following formula of the Japanese Society of Nephrology [16]: 194 x serum creatinine−1.094 x age-0.287 mL/min/1.73 m2, further multiplied by 0.739 for women. Lastly, because elevated blood glucose was shown to increase plasma AM levels [5,17], we excluded residents with hemoglobin A1c of 6.5 % or higher, fasting blood glucose of 126 mg/dL or higher, or taking glucose-lowering medicines, so as not to select those with diabetes mellitus. Of those clearing the exclusion criteria, 427 residents (141 males, 286 females), who had received checkups 5 times or more over 10 years prior to the examination year of this study, were chosen by retrospectively examining previous medical records.
Adrenomedullin and glucagon-like peptide-1 have additive effects on food intake in mice
2019, Biomedicine and PharmacotherapyAdrenomedullin Suppresses Vascular Endothelial Growth Factor–Induced Vascular Hyperpermeability and Inflammation in Retinopathy
2017, American Journal of PathologyAdrenomedullin: A potential therapeutic target for retinochoroidal disease
2016, Progress in Retinal and Eye ResearchCitation Excerpt :Several clinical studies have reported an association between plasma AM levels and DR. In type 1 diabetes, patients with DR show only a trend toward higher plasma AM levels (Garcia-Unzueta et al., 1998), whereas in type 2 diabetes, plasma AM levels in patients with DR are elevated (Caliumi et al., 2007; Nakamura et al., 1998; Zakareia et al., 2010). In addition, plasma AM levels are significantly elevated in patients with poorly controlled diabetes (Hayashi et al., 1997). Similar to elevated plasma AM levels, the vitreous AM levels in patients with DR are also elevated (Er et al., 2005; Ito et al., 2003; Lu et al., 2011; Udono et al., 2002).
Bench-to-bedside pharmacology of adrenomedullin
2015, European Journal of Pharmacology