Research LettersS100A12 (EN-RAGE) in monitoring Kawasaki disease
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S100A12 is expressed exclusively by granulocytes and acts independently from MRP8 and MRP14
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Cited by (121)
Leukocyte proteomics coupled with serum metabolomics identifies novel biomarkers and abnormal amino acid metabolism in Kawasaki disease
2021, Journal of ProteomicsCitation Excerpt :For example, the calcium-binding proteins S100P, A8, A9, and A12 exhibit higher expression levels during the acute phase compared with the healthy controls but decrease upon IVIG treatment. In line with our results, the mRNA level of the S100A12 gene [24], and the serum-derived S100A12 protein were shown to be increased during the acute phase and suggested as a critical inflammatory sign in KD children [25]. Moreover, the neutrophil-derived or circulating endothelial cell surface-derived S100A12 protein was previously reported to be not only increased in KD leukocytes [26,27] but also elevated in IVIG non-responders [28], and this molecule can activate coronary artery endothelial cells in an IL-1β-dependent manner [29].
S100 proteins: Diagnostic and prognostic biomarkers in laboratory medicine
2019, Biochimica et Biophysica Acta - Molecular Cell ResearchCitation Excerpt :S100A11 (calgizzarin) was associated with rheumatoid- and osteoarthritis and is an additional biomarker [211] to S100A/A9 and S100A12 for a more tailored diagnostic of inflammatory diseases. S100A12/calgranulin C is associated with the Kawasaki disease [212] and Mooren's ulcer [213] as well as atherosclerosis [214]. In addition, S100A12 seems to be more specific for inflammatory bowel disease in school aged children and adolescents when compared to established stool markers such as S100A8/A9 and lactoferrin [215,216].
Targeting S100A12 to Improve Angiogenesis and Accelerate Diabetic Wound Healing
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