Original articlesEffects of nitric oxide on matrix metalloproteinase-2 production by rheumatoid synovial cells
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Pathogenesis of Osteoarthritis
2016, Kelley and Firestein's Textbook of Rheumatology: Volumes 1-2, Tenth EditionRetinal pigment epithelium response to oxidant injury in the pathogenesis of early age-related macular degeneration
2012, Molecular Aspects of MedicineCitation Excerpt :Accordingly, dysregulated turnover of ECM is a major mechanism of disease pathogenesis in many tissue sites, including renal disease, atherosclerosis, lung disease and others (Aumailley and Gayraud, 1998; Belkhiri et al., 1997; Jacot et al., 1996; Kuzuya and Iguchi, 2003; Ohbayashi, 2002; Peten et al., 1992; Ries and Petrides, 1995; Schroen and Brinckerhoff, 1996). The capacity of oxidant injury to regulate production of ECM, especially to modulate the expression and activity of MMP-2 has been documented in different cell types (Ha and Lee, 2000; Hirai et al., 2001; Kinnula et al., 1998; Lee et al., 2003; Mattana et al., 1999). Unfortunately, minimal information is available concerning normal turnover in healthy BrM or dysregulated turnover in AMD eyes.
Pathogenesis of Osteoarthritis
2012, Kelley's Textbook of Rheumatology: Volume 1-2, Ninth EditionDifferentiation of human osteosarcoma cells by isolated phlorotannins is subtly linked to COX-2, iNOS, MMPs, and MAPK signaling: Implication for chronic articular disease
2009, Chemico-Biological InteractionsCitation Excerpt :These cytokines stimulate connective tissue cells and articular chondrocytes, and deduce a series of shared phosphorylation events within the cells that prompt transcriptional induction of MMPs. Also, it is likely that IL-1β upregulates other mediators, such as NO which may regulate MMPs by synovial cells and thus contributes to ECM degradation of articular components [26,27]. NO is an important messenger molecule functioning in vascular regulation, host immune defence, neurotransmission and other systems [28].
Biflavonoids isolated from Selaginella tamariscina regulate the expression of matrix metalloproteinase in human skin fibroblasts
2008, Bioorganic and Medicinal ChemistryElastokine-mediated up-regulation of MT1-MMP is triggered by nitric oxide in endothelial cells
2008, International Journal of Biochemistry and Cell Biology