Clinical studyHLA-DRB1 status affects endothelial function in treated patients with rheumatoid arthritis
Section snippets
Subjects
Patients who fulfilled the 1987 American College of Rheumatology classification criteria for rheumatoid arthritis (12) and who were treated by the same group of rheumatologists were recruited from the Hospital Xeral-Calde, Lugo, Spain. Patients were considered seropositive if a test for rheumatoid factor (by nephelometry) was positive at least twice during the course of the disease. The cohort constituted patients seen at the hospital outpatient clinic during a 1-month period (May 2001).
As the
Results
The patient group comprised 13 men and 42 women, whereas the control group comprised 6 men and 25 women (P = 0.7). The mean (± SD) age at the time of the study was 59.1 ± 12.3 years; the average age in the control group was 58.1 ± 10.7 years (P = 0.7). Serum cholesterol levels were similar in patients (206 ± 34 mg/dL) and controls (208 ± 34 mg/dL; P =0.8).
Discussion
Recent reports confirm an increased incidence of cardiovascular complications in patients with rheumatoid arthritis, perhaps up to fourfold greater than in the general population 17, 18. The increased risk of cardiovascular events was independent of traditional cardiovascular risk factors (18). Thus, the search for other predictors of cardiovascular disease is of great importance; vascular endothelial dysfunction, which is closely linked to the development of atherosclerosis, is one possible
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