Intracellular signaling in the neuro-immune axisThe role of adrenoceptor-mediated signals in the modulation of lymphocyte function
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2022, Brain, Behavior, and ImmunityCitation Excerpt :The loss of TH within T-lymphocytes would result in deficient production of all catecholamines, which canonically bind adrenergic receptors to influence T-lymphocyte functionality. There is a breadth of literature which has focused on the intracellular cascade that follows adrenergic receptor (AR) binding (Elkhatib and Case, 2019; Kin and Sanders, 2006; McAlees et al., 2011; Nance and Sanders, 2007; Sanders, 1995), and there are several potential pathways which could explain this relationship. In our work herein, we were able to rescue the attenuated ex vivo production of IL-17A and IL-22 by THT-KO T-lymphocytes through primarily NE supplementation.
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2007, Brain, Behavior, and ImmunityCitation Excerpt :Norepinephrine and epinephrine activate both α- and β-adrenergic receptors, of which α-adrenergic receptors are the predominantly expressed receptors in the skin (Ahlquist, 1976). Virtually all lymphoid cells express the β-adrenergic receptor with the exception of murine T helper 2 cells (Sanders, 1995). The responses of macrophages and neutrophils, both important players in wound healing, can be altered by adrenergic agonists (Barnes, 1999).
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