Autoimmunity to the cell cycle-dependent centromere protein p330d/CENP-F in disorders associated with cell proliferation
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Cited by (53)
Association of serum anti-centromere protein F antibodies with clinical response to infliximab in patients with rheumatoid arthritis: A prospective study
2020, Seminars in Arthritis and RheumatismCitation Excerpt :Centromere proteins (CENP) are the main components of the constricted regions of chromosomes [33], which play a major role in cell proliferation, mediating chromosome movement and sister chromatid separation during mitosis [34]. Historically, individual serum CENP autoantibodies have been related to different diseases: anti-CENP-A, anti-CENP-B, anti-CENP-C and anti-CENP-E antibodies are related to limited cutaneous systemic scleroderma (lcSSc) [35-38], anti-CENP-H putatively to Sjögren's syndrome [39], and anti-CENP-F to malignancies [34,40–43]. These autoantibodies, such as other anti-nuclear antibodies (ANAs) are commonly identified by indirect immunofluorescence (IIF).
IV Brazilian guidelines for autoantibodies on HEp-2 cells
2014, Revista Brasileira de ReumatologiaShedding fluorescent light into the antinuclear antibody world
2014, Revista Brasileira de ReumatologiaAutoantibodies to 60kDa SS-A/Ro yield a specific nuclear myriad discrete fine speckled immunofluorescence pattern
2013, Journal of Immunological MethodsAntinuclear antibodies: A contemporary nomenclature using HEp-2 cells
2010, Journal of AutoimmunityCitation Excerpt :Anti-midbody is most often found in patients with SSc or Raynaud’s syndrome [4,5]. This particular IIF staining pattern should be recognized with certainty since the main disease association is some form of cancer, most commonly lung and breast cancers [33]. The pattern was described like this (Fig. 20): “The most characteristic feature is seen in metaphase cells, where the pattern is constituted by 2 sets of dense large granules surrounding the chromosomal metaphase plate as a grip, often looking like a zipper.
Bioquiz: Anti-CENP-F (anticentromere F protein) antibodies
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