Elsevier

Genomics

Volume 13, Issue 3, July 1992, Pages 654-657
Genomics

The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14–q21, in the region of the IL-1α and IL-1β loci

https://doi.org/10.1016/0888-7543(92)90137-HGet rights and content

Abstract

The IL-1 receptor antagonist (IL-1RN) is a protein that binds to IL-1 receptors and inhibits the binding of IL-1α and IL-1β. As a consequence, the biological activity of these two cytokines is neutralized in physiological and pathophysiological immune and inflammatory responses. In this study, using a panel of somatic rodent-human cell hybrids, we show that the gene for the human interleukin-1 receptor antagonist (IL1RN) maps to the long arm of chromosome 2. Previously, we described a length variation polymorphism within the second intron of the IL-1RN gene (Steinkasserer et al., 1991, Nucleic Acids Res. 19: 5095). Segregation of this together with an IL-1α polymorphism, was followed in a panel of five CEPH families. Linkage analysis permitted the mapping of the IL-1RN gene to band q14–q21 in the region for the IL-1α and IL-1β loci. This study supports the view that an early gene duplication event resulted in the creation of an interleukin-1 gene family.

Reference (31)

  • BrissendenJ.E. et al.

    Mapping of transforming growth factor alpha gene on human chromosome 2 close to the breakpoint of the Burkitt's lymphoma t(2;8) variant

    Cancer Res.

    (1985)
  • CarterD.B. et al.

    Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein

    Nature

    (1990)
  • CornallR.J. et al.

    Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/Ity/Bcg genes on chromosome 1

    Nature

    (1991)
  • DinarelloC.A.

    Biology of interleukin 1

    FASEB J.

    (1988)
  • D'EustachioP. et al.

    Interleukin-1α and β genes: Linkage on chromosome 2 in the mouse

    Immunogenetics

    (1987)
  • Cited by (156)

    • Genetic and clinical risk factors of root resorption associated with orthodontic treatment

      2016, American Journal of Orthodontics and Dentofacial Orthopedics
    • The interleukin-1β-511 T>C (rs16944) gene polymorphism is associated with risk of developing silent myocardial ischemia in diabetic patients

      2015, Immunology Letters
      Citation Excerpt :

      The IL-1α and IL-1β genes encode for pro-inflammatory cytokines involved in host defense against infection, whereas the IL-1 receptor antagonist (IL-1ra), encoded by IL-1RN gene, is an anti-inflammatory non-signaling molecule that competes for receptor binding with the agonist pro-inflammatory IL-1, IL-1α and IL-1β [14,15]. The IL-1β, IL-1F10.3 and IL-1RN genes are located on chromosome 2 at position 2q14-2q21 [16]. Four single nucleotide polymorphisms (SNPs) have been described for these genes, one in the promoter region of the IL-1β gene [position-511 T > C (rs16944)], one in exon 2 of the coding region [T493C (rs3811058)] of the IL-1F10.3 gene, and two in the coding region of the IL-1RN gene, one triallelic polymorphism at in the exon 4 position T454C/A (rs315952), and other in the exon 2 at position T235C (rs419598).

    View all citing articles on Scopus
    View full text