The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14–q21, in the region of the IL-1α and IL-1β loci
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2016, American Journal of Orthodontics and Dentofacial OrthopedicsThe interleukin-1β-511 T>C (rs16944) gene polymorphism is associated with risk of developing silent myocardial ischemia in diabetic patients
2015, Immunology LettersCitation Excerpt :The IL-1α and IL-1β genes encode for pro-inflammatory cytokines involved in host defense against infection, whereas the IL-1 receptor antagonist (IL-1ra), encoded by IL-1RN gene, is an anti-inflammatory non-signaling molecule that competes for receptor binding with the agonist pro-inflammatory IL-1, IL-1α and IL-1β [14,15]. The IL-1β, IL-1F10.3 and IL-1RN genes are located on chromosome 2 at position 2q14-2q21 [16]. Four single nucleotide polymorphisms (SNPs) have been described for these genes, one in the promoter region of the IL-1β gene [position-511 T > C (rs16944)], one in exon 2 of the coding region [T493C (rs3811058)] of the IL-1F10.3 gene, and two in the coding region of the IL-1RN gene, one triallelic polymorphism at in the exon 4 position T454C/A (rs315952), and other in the exon 2 at position T235C (rs419598).
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