Substance P- and CGRP-immunoreactive nerves in bone

doi:10.1016/0196-9781(88)90023-X

Peptides

Volume 9, Issue 1, January–February 1988, Pages 165-171

https://doi.org/10.1016/0196-9781(88)90023-X Get rights and content

Abstract

The present study demonstrates the occurrence of substance P (SP)- and calcitonin gene related peptide (CGRP)-immunoreactive nerve fibres in bone, bone marrow, periosteum, synovial membrane and soft tissues adjacent to the bone. The distribution pattern of the two types of nerves was similar, although the CGRP-positive fibres generally were more numerous. Both types of nerves were particularly abundant near the epiphyseal plate, in the bone marrow of patella and epiphyses, and in the periosteum. Many SP- and CGRP-immunoreactive fibres were also observed around blood vessels.

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^☆: These results have in part been reported at the 33rd Annual Meeting, Orthopaedic Research Society, San Francisco, January, 1987 [2].

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Substance P- and CGRP-immunoreactive nerves in bone☆

Abstract

Regul Pept

Life Sci

Neurosci Lett

Lancet

Brain Res

Neuroscience

Neuropeptides

Brain Res

Neuropeptides

Mol Cell Endocrinol

Regul Pept

Eur J Pharmacol

Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide product

Nature

Innervation of bone tissue by sensory nerve fibres

Calcitonin gene-related peptide is a potent vasodilator

Nature

Cutaneous mechanoreceptors and nociceptors

Fluorescent antibody method

Substance P immunoreactive neurones following neonatal administration of capsaicin

Arch Pharmacol

Human synthetic calcitonin gene-related peptide inhibits bone resorption

Endocrinology

An unidentified depressor substance in certain tissue extracts

J Physiol

Decrease of substance P in primary afferent neurones and impairment of neurogenic plasma extravasation by capsaicin

Br J Pharmacol

Contribution to the theory that substance P has a trasmitter role in sensitive pathway

Med Exp (Basel)