Evaluation of pilocarpine-loaded albumin particles as controlled drug delivery systems for the eye. II. Co-administration with bioadhesive and viscous polymers

https://doi.org/10.1016/0168-3659(94)00059-4Get rights and content

Abstract

The aim of the present investigation was to investigate the influence of various polymers at different concentrations on the in vivo activity of pilocarpine-loaded albumin nanoparticles. It was speculated that co-administration with viscous or bioadhesive polymers would increase the time of residence in the eye of the drug-loaded particle systems, and hence the drug bioavailability. For this purpose, different formulations containing bioadhesive (hyaluronic acid, mucin, sodium car☐ymethylcellulose, and polyacrylic acid) or viscosity-enhancing polymers (methylcellulose, polyvinyl alcohol, and hydroxypropylmethylcellulose) were tested in rabbits for miotic effect and reduction of intraocular pressure (IOP, betamethasone model). In the presence of some polymers, the nanoparticles induced a significantly improved pharmacological response when compared with particle dispersions in buffer or with particle-free polymeric vehicles. Bioadhesive polymers exhibited superior effects with respect to viscous polymers: the best results for miotic response and IOP reduction were observed with mucin. It can be assumed that coadministration of particles with these polymers leads to an improved adhesion to the precomeal/conjunctival mucin layer and hence to a prolongation of the residence time of the medication in the eye.

Reference (41)

  • Lu¨tjen-DrecollE. et al.

    Visualisation of hyaluronic acid in the anterior segment of rabbit and monkey eyes

    Exp. Eye Res.

    (1990)
  • ParkK. et al.

    Bioadhesive polymers as platforms for oral-controlled drug delivery: method to study bioadhesion

    Int. J. Pharm.

    (1984)
  • BarryB.W. et al.

    The rheological properties of carbopol gels I: Continuous shear and creep properties of carbopol gels

    Int. J. Pharm.

    (1979)
  • NisizawaK. et al.

    The composition and properties of the mucin clot from cattle submaxillary glands

    Arch. Oral. Biol.

    (1959)
  • ProustJ.E. et al.

    Mucin thin film as model of the tear film rupture

    J. Coll. Interface Sci.

    (1984)
  • LiV.H.L. et al.

    Solution viscosity effects on the ocular disposition of cromolyn sodium in the albino rabbit

    Int. J. Pharm.

    (1989)
  • SaariM. et al.

    Effect of vehicle on pilocarpine-induced miosis

    Acta Ophthalmol.

    (1975)
  • LoucasS.P. et al.

    Solid state ophthalmic dosage system II: Use of polyuronic acid in effecting prolonged delivery of pilocarpine in the eye

    Metabol. Ophthalmol.

    (1976)
  • DaviesN.M. et al.

    The influence of a mucoadhesive polymer on the bioavailability of pilocarpine

  • CamberO. et al.

    Sodium hyaluronate as an ophthalmic vehicle: Some factors governing the effect of pilocarpine in rabbits

    Curr. Eye Res.

    (1989)
  • Cited by (93)

    • Polymer-based bionanomaterials for targeted drug delivery

      2022, Fundamentals of Bionanomaterials
    • Gellan gum based gastroretentive tablets for bioavailability enhancement of cilnidipine in human volunteers

      2021, International Journal of Biological Macromolecules
      Citation Excerpt :

      Gellan gum is a hydrophilic, linear anionic heteropolysaccharide obtained from Pseudomonas elodea [27,28] with a tetrasaccharide repeating unit of glucuronic acid, rhamnose and glucose residues [29–31]. It is a food additive [32] but due to its characteristic property of undergoing ionic gelation in presence of mono- and divalent cations this novel polymer [33] is now being widely used in pharmaceuticals [34] including oral [35–38], ophthalmic [39–44], nasal [45–48] and transdermal [49–51] applications as in-situ gelling agent [52], mucoadhesive agent [53,54] and as sustained or controlled release matrix polymer [55–57]. Considering its innumerable applications, gellan gum was employed as swellable hydrophilic mucoadhesive polymer in the present study.

    • Neuroprotective effect of melatonin loaded in ethylcellulose nanoparticles applied topically in a retinal degeneration model in rabbits

      2020, Experimental Eye Research
      Citation Excerpt :

      ME was obtained from Saporiti S.A.C.I.F.I.A (Buenos Aires, Argentina), ethylcellulose (EC; MW = 90–110 mPa s) was kindly donated by Colorcon® (Buenos Aires, Argentina), sorbitan monostearate Span 60® was purchased from Resikem S.A. (Buenos Aires, Argentina), and polysorbate 80 Tween 80® was supplied by TodoDroga® (Córdoba, Argentina). Medium chain triglycerides Miglyol 821® (MCT) was acquired from Etilfarma S.A. (Buenos Aires, Argentina), PBS Solution (pH = 6.8) was prepared according to Zimmer et al. (Zimmer et al., 1995). Glutamate, L-butionine-S, R-sulfoximine, proteinase K, hydrogen peroxide, methyl green, glutaraldehyde, and formaldehyde were purchased from Sigma-Aldrich (St. Louis, Missouri, USA).

    • Gellan gum in drug delivery applications

      2019, Natural Polysaccharides in Drug Delivery and Biomedical Applications
    View all citing articles on Scopus
    View full text