Immunologically ignorant autoreactive T cells, epitope spreading and repertoire limitation

https://doi.org/10.1016/0167-5699(95)80091-3Get rights and content

Abstract

The factors that may cause antigen-presenting cells to alter the pattern of protein processing and presentation to autoreactive T cells, and thereby stimulate autoimmune disease, are currently under debate. In this article, Chris Elson and colleagues suggest that cytokines associated with T helper 1 (Th1) cells alter the processing of proteins and that this effect can be counteracted by Th2-associated cytokines.

References (40)

  • ElsonC.J.

    Immunol. Today

    (1980)
  • HooperD.C.

    Immunol. Today

    (1987)
  • HooperD.C. et al.

    Cell. Immunol.

    (1987)
  • OldstoneM.B.A. et al.

    Cell

    (1991)
  • BeverleyP.C.L.

    Immunol. Today

    (1990)
  • PlebanskiM. et al.

    J. Immunol. Methods

    (1994)
  • LehmannP.V. et al.

    Immunol. Today

    (1993)
  • MamulaM.J. et al.

    Immunol. Today

    (1993)
  • RossmanM.D. et al.

    Cell. Immunol.

    (1990)
  • ThompsonS.J. et al.

    Immunol. Lett.

    (1993)
  • MamulaM.J.

    J. Exp. Med.

    (1993)
  • OhashiP.S. et al.

    Cell

    (1991)
  • BarkerR.N. et al.

    Eur. J. Immunol.

    (1994)
  • PlebanskiM. et al.

    Immunology

    (1992)
  • PlebanskiM. et al.

    Eur. J. Immunol.

    (1992)
  • MossmanT.R. et al.

    Immunol. Today

    (1987)
  • BedwellA.E. et al.

    Scand. J. Immunol.

    (1987)
  • ThompsonS.J. et al.

    Eur. J. Immunol.

    (1990)
  • ThompsonS.J. et al.

    Autoimmunity

    (1991)
  • BarkerR.N. et al.

    Autoimmunity

    (1992)
  • Cited by (130)

    • Autoimmune hemolytic anemia

      2019, The Autoimmune Diseases
    • Autoimmune Hemolytic Anemia

      2013, The Autoimmune Diseases: Fifth Edition
    View all citing articles on Scopus

    The authors wish to express their thanks to M.J. Day and L.M. Stasiuk for helpful discussion. R.N.B. is a Wellcome Research Fellow; S.J.T. is an Arthritis and Rheumatism Council Research Fellow.

    1

    Christopher J. Elson, Robert N. Barker, Stephen J. Thompson and Neil A. Williams are at the University of Bristol Dept of Pathology and Microbiology, Bristol, UK BS8 1TD.

    View full text