ReviewGuilt by association: HLA-B27 and ankylosing spondylitis
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Cited by (370)
A Road Map of the Axial Spondyloarthritis Continuum
2022, Mayo Clinic ProceedingsModulation of natural HLA-B*27:05 ligandome by ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 2 (ERAP2)
2020, Molecular and Cellular ProteomicsMetal-triggered conformational reorientation of a self-peptide bound to a disease-associated HLA-B∗27 subtype
2019, Journal of Biological ChemistryCitation Excerpt :Explanatory difficulties connected with the fact that only certain HLA alleles are associated with a particular disease could be accounted for by assuming that conformational reorientations of a peptide as described here for the pVIPR-B*27:05 complex following exposure to Cu2+ or Ni2+ are less likely in subtypes that lack a disease association, such as B*27:09. As mentioned before, a particular arthritogenic peptide (24), possibly derived from a microorganism, would be superfluous in this scenario. A higher degree of molecular dynamics in the AS-associated subtypes B*27:05 and B*27:04 than in the nonassociated B*27:09 and B*27:06 molecules (15) supports the idea that HLA-B*27 polymorphisms, molecular flexibility, concomitant peculiarities in peptide repertoire, and presentation and ultimately AS association are intimately connected with each other.
Label-Free Detection of Ankylosing Spondylitis by IGZO Thin-Film Transistor Biosensor
2024, Hsi-An Chiao Tung Ta Hsueh/Journal of Xi'an Jiaotong University