Expression of cell adhesion molecules in inflammatory myopathies

doi:10.1016/0165-5728(95)00045-4

Journal of Neuroimmunology

Volume 59, Issues 1–2, June 1995, Pages 185-194

https://doi.org/10.1016/0165-5728(95)00045-4 Get rights and content

Abstract

We examined the expression of cell adhesion molecules in 25 cases of inflammatory myopathies. Inflammatory myopathies showed upregulation of adhesion molecules. ICAM-1 was strongly expressed on endothelial cells as well as on fibroblasts and infiltrating leukocytes while the expression of VCAM-1, similar in its distribution, was much weaker. A few muscle fibers in polymyositis revealed sarcolemmal labeling for ICAM-1. ELAM-1 showed only weak expression on vessels. The inflammatory cellular infiltrates contained varying amounts of cells bearing the VCAM-1 ligand VLA-4 and the ELAM-1 ligand SLe^x as well as large amounts of cells expressing LFA-1α and β, ligands of ICAM-1.

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