Immunoglobulin-deficient rats fail to develop experimental allergic encephalomyelitis
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Discovery and Function of B-Cell IgD Low (BD<inf>L</inf>) B Cells in Immune Tolerance
2021, Journal of Molecular BiologyCitation Excerpt :Here, we provide the history from our first realization that B-cell regulation is linked to Treg, to discovering the mechanism and then finally to the characterization of a new B-cell subset that interacts with Treg to promote their homeostasis thereby maintaining immune tolerance [3,6,7]. To study a role for B cells in EAE, early studies depleted B cells in rats from birth with anti-IgM antibodies, in which EAE was induced by myelin basic protein (MBP) or spinal cord homogenate [8]. These rats were resistant to EAE induction, which upon further examination was due to the generation of anti-MBP antibodies [9].
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2014, Journal of NeuroimmunologyCitation Excerpt :The EAE model has recently led to numerous insights into B cell function in the pathogenesis of MS. Early investigations into the role of B cells in EAE utilized injections of anti-IgM antibodies to deplete B cells in rats prior to EAE induction. In these early studies, depletion of B cells prevented the induction of EAE (Willenborg and Prowse, 1983). In follow-up experiments, EAE could be induced if an experimental animal received MBP-specific antiserum in addition to anti-IgM antibodies (Willenborg et al., 1986).