Enhancement of the interleukin 2 receptor expression on T cells by multiple B-lymphotropic lymphokines

doi:10.1016/0165-2478(87)90032-0

Immunology Letters

Volume 15, Issue 3, July 1987, Pages 249-253

https://doi.org/10.1016/0165-2478(87)90032-0 Get rights and content

Abstract

Three new human lymphokines, interleukin-5, BSF-2 and BSF-MP6, were shown to be active in the enhancement of the IL-2 receptor expression on T cells, although they do not stimulate growth of the T cells.

References (26)

J.J. Oppenheim et al.
Immunol. Today
(1986)
T. Noma et al.
Biochem. Biophys. Res. Commun.
(1986)
T. Kishimoto
Annu. Rev. Immunol.
(1985)
Y. Noma et al.
Nature
(1986)
F. Lee et al.
T. Yokota et al.
T. Kinashi et al.
Nature
(1986)
C. Azuma et al.
Nucleic Acid Res.
(1986)
T. Hirano et al.
Nature
(1986)
G. Haegeman et al.
Eur. J. Biochem.
(1986)

A. Zilberstein et al.

EMBO J.

(1986)

E. Severinson et al.

Eur. J. Immunol.

(1987)

Y. Hamaguchi et al.

J. Exp. Med.

(1987)

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Enhancement of the interleukin 2 receptor expression on T cells by multiple B-lymphotropic lymphokines

Abstract

Immunol. Today

Biochem. Biophys. Res. Commun.

Annu. Rev. Immunol.

Nature

Nature

Nucleic Acid Res.

Nature

Eur. J. Biochem.

EMBO J.

Eur. J. Immunol.

J. Exp. Med.