Original articleInhibition of methylprednisolone elimination in the presence of erythromycin therapy☆
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2004, Journal of the American Dental AssociationCitation Excerpt :The corticosteroid that seems most prone to these interactions is methylprednisolone,58–64 an agent frequently administered in a six-day, 21-dose regimen (a dose-pack) to reduce postoperative swelling after dental impaction surgery. CYP3A4-inhibitor drugs that have been documented to cause the accumulation of methylprednisolone include the macrolide antibiotic drugs erythromycin and clarithromycin,58,59 the azole anti-fungal drugs itraconazole and ketoconazole,60,61 the calcium-channel–blocking agents diltiazem and mibefradil62,63 and 200 mL of double-strength grapefruit juice.64 It is likely that other CYP3A4 inhibitors also could interact adversely with methylprednisolone.
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Supported in part by grants No. HL-30513 from the Heart, Lung and Blood Institutes, No. 24211 from the National Institutes of General Medical Sciences, and No. AI-14198 from the National Institutes of Allergy and Infectious Diseases (Multidisciplinary Study of Asthma).
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Present address: Department of Pediatrics, University of North Carolina, Chapel Hill.